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Adora2b adenosine A2b receptor [ Mus musculus (house mouse) ]

Gene ID: 11541, updated on 2-Nov-2024

Summary

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Official Symbol
Adora2bprovided by MGI
Official Full Name
adenosine A2b receptorprovided by MGI
Primary source
MGI:MGI:99403
See related
Ensembl:ENSMUSG00000018500 AllianceGenome:MGI:99403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2b; A2BR; A2BAR; AA2BR; ARA2B
Summary
Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled adenosine receptor signaling pathway and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including positive regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and positive regulation of guanylate cyclase activity. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 18.0), bladder adult (RPKM 15.8) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Adora2b in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62139810..62157278)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62248984..62266452)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1 Neighboring gene predicted gene, 39988 Neighboring gene STARR-seq mESC enhancer starr_29694 Neighboring gene predicted gene, 39985 Neighboring gene STARR-seq mESC enhancer starr_29695 Neighboring gene STARR-seq mESC enhancer starr_29696 Neighboring gene STARR-positive B cell enhancer ABC_E9139 Neighboring gene zinc finger SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene anaphase-promoting complex subunit 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A2B adenosine receptor induces protective antihelminth type 2 immune responses. Patel N, et al. Cell Host Microbe, 2014 Mar 12. PMID 24629340
  2. Membrane cholesterol oxidation downregulates atrial β-adrenergic responses in ROS-dependent manner. Ursan R, et al. Cell Signal, 2020 Mar. PMID 31857238
  3. Distinct roles for the A2B adenosine receptor in acute and chronic stages of bleomycin-induced lung injury. Zhou Y, et al. J Immunol, 2011 Jan 15. PMID 21149612, Free PMC Article
  4. Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension. Mertens TCJ, et al. Front Physiol, 2018. PMID 29910735, Free PMC Article
  5. A2B adenosine receptors prevent insulin resistance by inhibiting adipose tissue inflammation via maintaining alternative macrophage activation. Csóka B, et al. Diabetes, 2014 Mar. PMID 24194503, Free PMC Article

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis.
    Title: ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis.
  2. Adenosine A2B receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia.
    Title: Adenosine A(2B) receptor agonist improves epidermal barrier integrity in a murine model of epidermal hyperplasia.
  3. Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
    Title: Klotho Null Mutation Involvement in Adenosine A2B Receptor-Related Skeletal Muscle Degeneration.
  4. Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
    Title: Targeting myocardial equilibrative nucleoside transporter ENT1 provides cardioprotection by enhancing myeloid Adora2b signaling.
  5. CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
    Title: CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer.
  6. Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.
    Title: Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.
  7. Adenosine A2B receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
    Title: Adenosine A(2B) receptor down-regulates metabotropic glutamate receptor 5 in astrocytes during postnatal development.
  8. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
    Title: Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity.
  9. Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming.
    Title: Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming.
  10. PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
    Title: PMN-derived netrin-1 attenuates cardiac ischemia-reperfusion injury via myeloid ADORA2B signaling.
Submit: New GeneRIF Correction See all GeneRIFs (118)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC144574, MGC144575

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled adenosine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cGMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of catecholamine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of chronic inflammatory response to non-antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within relaxation of vascular associated smooth muscle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to angiotensin ISO
Inferred from Sequence Orthology
more info
  
involved_in vasodilation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenosine receptor A2b
Names
A2b, Rs

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007413.4 → NP_031439.2  adenosine receptor A2b

    See identical proteins and their annotated locations for NP_031439.2

    Status: VALIDATED

    Source sequence(s)
    AL596110
    Consensus CDS
    CCDS24822.1
    UniProtKB/Swiss-Prot
    Q60614, Q8BXI2
    UniProtKB/TrEMBL
    Q8BK41
    Related
    ENSMUSP00000018644.3, ENSMUST00000018644.3
    Conserved Domains (2) summary
    pfam00001
    Location:24 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:17 → 134
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62139810..62157278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60614.2 GenPept UniProtKB/Swiss-Prot:Q60614

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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