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Aebp2 AE binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 11569, updated on 2-Nov-2024

Summary

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Official Symbol
Aebp2provided by MGI
Official Full Name
AE binding protein 2provided by MGI
Primary source
MGI:MGI:1338038
See related
Ensembl:ENSMUSG00000030232 AllianceGenome:MGI:1338038
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230313N05Rik
Summary
Enables transcription coregulator activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including autopod; brain ventricular layer; early conceptus; genitourinary system; and gut. Used to study Hirschsprung's disease and Waardenburg syndrome. Orthologous to human AEBP2 (AE binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.4), CNS E11.5 (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aebp2 in Genome Data Viewer
Location:
6 G2; 6 70.71 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (140567480..140624198)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (140622454..140678472)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17665 Neighboring gene pleckstrin homology domain containing, family A member 5 Neighboring gene predicted gene 5051 Neighboring gene STARR-seq mESC enhancer starr_17672 Neighboring gene STARR-seq mESC enhancer starr_17677 Neighboring gene STARR-positive B cell enhancer mm9_chr6:140641102-140641403 Neighboring gene STARR-seq mESC enhancer starr_17678 Neighboring gene STARR-positive B cell enhancer ABC_E9107 Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:140765370-140765671 Neighboring gene STARR-seq mESC enhancer starr_17681 Neighboring gene STARR-seq mESC enhancer starr_17683 Neighboring gene STARR-seq mESC enhancer starr_17684 Neighboring gene predicted gene, 30524 Neighboring gene ribosomal protein L11 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2. Kim H, et al. Nucleic Acids Res, 2009 May. PMID 19293275, Free PMC Article
  2. Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs. Grijzenhout A, et al. Development, 2016 Aug 1. PMID 27317809, Free PMC Article
  3. AEBP2 as a transcriptional activator and its role in cell migration. Kim H, et al. Genomics, 2015 Feb. PMID 25451679, Free PMC Article
  4. Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression. He GP, et al. J Biol Chem, 1999 May 21. PMID 10329662
  5. Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA. Davidovich C, et al. Mol Cell, 2015 Feb 5. PMID 25601759, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESC/E(Z) complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein AEBP2
Names
adipocyte enhancer-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005605.3 → NP_001005605.1  zinc finger protein AEBP2 isoform 1

    See identical proteins and their annotated locations for NP_001005605.1

    Status: VALIDATED

    Source sequence(s)
    AC133098, AEKQ02102408
    Consensus CDS
    CCDS20673.1
    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000084896.5, ENSMUST00000087614.11
    Conserved Domains (2) summary
    COG5048
    Location:210 → 332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001309436.2 → NP_001296365.1  zinc finger protein AEBP2 isoform 4

    See identical proteins and their annotated locations for NP_001296365.1

    Status: VALIDATED

    Source sequence(s)
    AC133098, AEKQ02102408
    Consensus CDS
    CCDS80631.1
    UniProtKB/TrEMBL
    A0AA74KSU7
    Related
    ENSMUSP00000125479.2, ENSMUST00000161335.8
    Conserved Domains (2) summary
    COG5048
    Location:3 → 110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:37 → 57
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001309437.1 → NP_001296366.1  zinc finger protein AEBP2 isoform 4

    See identical proteins and their annotated locations for NP_001296366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, alternate 3' coding region and cause translation initiation at a downstream start codon, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus and distinct C-terminus, compared to isoform 1. Both variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AC133098, AK045838
    Consensus CDS
    CCDS80631.1
    UniProtKB/TrEMBL
    A0AA74KSU7
    Related
    ENSMUSP00000124148.2, ENSMUST00000160836.8
    Conserved Domains (2) summary
    COG5048
    Location:3 → 110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:37 → 57
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_009637.5 → NP_033767.2  zinc finger protein AEBP2 isoform 3

    See identical proteins and their annotated locations for NP_033767.2

    Status: VALIDATED

    Source sequence(s)
    AC133098, AEKQ02102408
    Consensus CDS
    CCDS39689.2
    UniProtKB/Swiss-Prot
    Q6PF91, Q78HB0, Q8BGV1, Q8CE51, Q9Z248
    Related
    ENSMUSP00000092993.6, ENSMUST00000095350.12
    Conserved Domains (3) summary
    COG5048
    Location:210 → 332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308 → 334
    zf-H2C2_2; Zinc-finger double domain

  5. NM_178803.3 → NP_848918.1  zinc finger protein AEBP2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC133098, AEKQ02102408
    Consensus CDS
    CCDS20674.1
    UniProtKB/TrEMBL
    A0AA74KSU7
    Related
    ENSMUSP00000032359.9, ENSMUST00000032359.15
    Conserved Domains (2) summary
    COG5048
    Location:3 → 110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:37 → 57
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    140567480..140624198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506909.4 → XP_006506972.1  zinc finger protein AEBP2 isoform X3

    See identical proteins and their annotated locations for XP_006506972.1

    UniProtKB/TrEMBL
    A0AA74KSU7
    Conserved Domains (2) summary
    COG5048
    Location:3 → 110
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:37 → 57
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006506905.3 → XP_006506968.1  zinc finger protein AEBP2 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:210 → 332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:308 → 334
    zf-H2C2_2; Zinc-finger double domain

  3. XM_006506906.1 → XP_006506969.1  zinc finger protein AEBP2 isoform X2

    See identical proteins and their annotated locations for XP_006506969.1

    UniProtKB/Swiss-Prot
    Q9Z248
    Related
    ENSMUSP00000123897.4, ENSMUST00000162903.8
    Conserved Domains (2) summary
    COG5048
    Location:210 → 332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z248.2 GenPept UniProtKB/Swiss-Prot:Q9Z248

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