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LOC116183066 CRISPRi-validated cis-regulatory element chr6.3824 [ Homo sapiens (human) ]

Gene ID: 116183066, updated on 10-Oct-2023

Summary

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Gene symbol
LOC116183066
Gene description
CRISPRi-validated cis-regulatory element chr6.3824
Gene type
biological region
Feature type(s)
regulatory: transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region represents a DNase I hypersensitive site (DHS) that was predicted to be an enhancer by the ENCODE (ENCyclopedia Of DNA Elements) project based on various combinations of H3K27 acetylation and binding of p300, GATA1 and RNA polymerase II in K562 erythroleukemia cells. It was validated as a cis-regulatory element for the PNRC1 (proline rich nuclear receptor coactivator 1) gene on chromosome 6 based on multiplex CRISPR/Cas9-mediated perturbation in K562 cells. [provided by RefSeq, Oct 2019]
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Genomic context

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Location:
6q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89035367..89036201)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90244034..90244868)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (89745086..89745920)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene uncharacterized LOC124901521 Neighboring gene MPRA-validated peak5946 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24816 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:89438317-89438876 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:89439995-89440553 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:89440554-89441112 Neighboring gene MPRA-validated peak5947 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:89536615-89537462 Neighboring gene MPRA-validated peak5948 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:89671756-89672682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24817 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:89673400-89673634 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:89682583-89683204 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:89731277-89731892 Neighboring gene CYCS pseudogene 16 Neighboring gene MPRA-validated peak5950 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:89767403-89767931 Neighboring gene adaptor related protein complex 4 subunit sigma 1 pseudogene Neighboring gene RNA, U2 small nuclear 61, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens. Gasperini M, et al. Cell, 2019 Jan 10. PMID 30612741, Free PMC Article
  2. An integrated encyclopedia of DNA elements in the human genome. ENCODE Project Consortium. Nature, 2012 Sep 6. PMID 22955616, Free PMC Article
  3. The accessible chromatin landscape of the human genome. Thurman RE, et al. Nature, 2012 Sep 6. PMID 22955617, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_066796.1 

    Range
    101..935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    89035367..89036201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    90244034..90244868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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