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Ak1 adenylate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 11636, updated on 2-Nov-2024

Summary

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Official Symbol
Ak1provided by MGI
Official Full Name
adenylate kinase 1provided by MGI
Primary source
MGI:MGI:87977
See related
Ensembl:ENSMUSG00000026817 AllianceGenome:MGI:87977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak-1; B430205N08Rik
Summary
Enables adenylate kinase activity. Predicted to be involved in inosine biosynthetic process; positive regulation of D-glucose transmembrane transport; and purine ribonucleotide metabolic process. Located in outer dense fiber. Is expressed in several structures, including heart; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in heart adult (RPKM 107.3), testis adult (RPKM 39.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ak1 in Genome Data Viewer
Location:
2 B; 2 22.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32511770..32525070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32621758..32635058)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene predicted gene, 52551 Neighboring gene predicted gene, 23369 Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene STARR-positive B cell enhancer ABC_E10096 Neighboring gene STARR-seq mESC enhancer starr_04202 Neighboring gene STARR-seq mESC enhancer starr_04203 Neighboring gene STARR-seq mESC enhancer starr_04204 Neighboring gene endoglin Neighboring gene microRNA 1954 Neighboring gene predicted gene, 26236

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism. Janssen E, et al. J Biol Chem, 2003 Apr 11. PMID 12562761
  2. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Carrasco AJ, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11390963, Free PMC Article
  3. Compromised energetics in the adenylate kinase AK1 gene knockout heart under metabolic stress. Pucar D, et al. J Biol Chem, 2000 Dec 29. PMID 11006295
  4. Adenylate kinase 1 knockout mice have normal thiamine triphosphate levels. Makarchikov AF, et al. Biochim Biophys Acta, 2002 Oct 21. PMID 12379473
  5. Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice. Zhang SJ, et al. Acta Physiol (Oxf), 2008 Mar. PMID 17973952

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
    Title: The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
  2. Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
    Title: Activation of AMP kinase ameliorates kidney vascular dysfunction, oxidative stress and inflammation in rodent models of obesity.
  3. Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stressdagger.
    Title: Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress†.
  4. In addition to AK1 and AK2, which we previously demonstrated are present in outer dense fibers and mitochondrial sheath of the mouse sperm tail, we show that another AK, AK8, is present in a third flagellar compartment, the axoneme.
    Title: Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm.
  5. CaMKIalpha regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
    Title: CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
  6. identified hitherto unrecognized soluble forms of AK1 and NTPDase1/CD39 that contribute in the active cycling between the principal platelet-recruiting agent ADP and other circulating nucleotides
    Title: Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities.
  7. Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.
    Title: Gated dynamic 31P MRS shows reduced contractile phosphocreatine breakdown in mice deficient in cytosolic creatine kinase and adenylate kinase.
  8. Adenylate kinase-1 knockout mice have a normal capacity for contraction-mediated glucose uptake.
    Title: Activation of glucose transport and AMP-activated protein kinase during muscle contraction in adenylate kinase-1 knockout mice.
  9. Defective metabolic signaling in Ak1 gene knock-out hearts compromises post-ischemic coronary reflow.
    Title: Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow.
  10. The purpose of this study was to determine whether adenylate kinase 1 deficiency would result in sufficient ADP accumulation to be visible using (31)P-NMRS during the high energy demands of frequent in situ tetanic contractions.
    Title: 31P-NMR observation of free ADP during fatiguing, repetitive contractions of murine skeletal muscle lacking AK1.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables (deoxy)adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside diphosphate kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to phosphotransferase activity, phosphate group as acceptor ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ADP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in AMP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in AMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in inosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside monophosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside triphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in outer dense fiber IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate kinase isoenzyme 1
Names
cytosolic adenylate kinase
NP_001185719.1
NP_001185720.1
NP_001185721.1
NP_067490.1
XP_030102669.1
XP_036013552.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198790.1 → NP_001185719.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185719.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    AK046613, BC014802
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Related
    ENSMUSP00000108903.3, ENSMUST00000113278.9
    Conserved Domains (1) summary
    TIGR01360
    Location:6 → 193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

  2. NM_001198791.1 → NP_001185720.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185720.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BC014802, BY130582
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Related
    ENSMUSP00000108902.2, ENSMUST00000113277.8
    Conserved Domains (1) summary
    TIGR01360
    Location:6 → 193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

  3. NM_001198792.1 → NP_001185721.1  adenylate kinase isoenzyme 1 isoform 2

    See identical proteins and their annotated locations for NP_001185721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs at the 5' UTR and 5' coding region, compared to variant 1. The encoded protein (isoform 2) has a shorter, distinct N-terminus compared to isoform 1. Variants 2, 3, and 4 encode the same protein (isoform 2).
    Source sequence(s)
    BC014802, BY333336
    Consensus CDS
    CCDS57167.1
    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6 → 193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

  4. NM_021515.3 → NP_067490.1  adenylate kinase isoenzyme 1 isoform 1

    See identical proteins and their annotated locations for NP_067490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC014802, CF950379
    Consensus CDS
    CCDS15924.1
    UniProtKB/Swiss-Prot
    Q9R0Y5
    Related
    ENSMUSP00000068479.5, ENSMUST00000068271.5
    Conserved Domains (1) summary
    TIGR01360
    Location:22 → 209
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    32511770..32525070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246809.2 → XP_030102669.1  adenylate kinase isoenzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6 → 193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily

  2. XM_036157659.1 → XP_036013552.1  adenylate kinase isoenzyme 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AK80, Q542C5, Q9R0Y4, Q9R0Y5
    Conserved Domains (1) summary
    TIGR01360
    Location:6 → 193
    aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0Y5.1 GenPept UniProtKB/Swiss-Prot:Q9R0Y5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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