Sec14l2 SEC14-like lipid binding 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sec14l2provided by RGD
Official Full Name: SEC14-like lipid binding 2provided by RGD
Primary source: RGD:621779
See related: EnsemblRapid:ENSRNOG00000004672 AllianceGenome:RGD:621779
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spf
Summary: Enables enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 499.5), Brain (RPKM 140.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (83197384..83222059, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (78973805..78998480, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (84335594..84360354, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
Title: Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
Sec14l2 stimulates HMG-CoA reductase in hepatoma cell cultures.
Title: Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.
overexpression of SEC14L1 modestly decreases high affinity choline transport activity
Title: SEC14-like protein 1 interacts with cholinergic transporters.
The activation of SPF by PKA suggests that cholesterol synthesis can be rapidly modulated in response to external stimuli by changes in cAMP levels, and that this regulation is dependent on an as yet undefined interaction with Golgi.
Title: Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139394 (e-PCR)
- UniSTS:221480

BF387395 (e-PCR)
- UniSTS:244331

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cholesterol biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SEC14-like protein 2

Names: TAP; alpha-tocopherol-associated protein; squalene transfer protein; supernatant protein factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053801.2 → NP_446253.2 SEC14-like protein 2

See identical proteins and their annotated locations for NP_446253.2

Status: PROVISIONAL

Source sequence(s)

BC089785

UniProtKB/TrEMBL

F7F3C3, Q5EBD0

Related

ENSRNOP00000006542.5, ENSRNOT00000006542.6

Conserved Domains (2) summary

smart00516
Location:76 → 244

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:13 → 59

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

83197384..83222059 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251154.5 → XP_006251216.1 SEC14-like protein 2 isoform X1

UniProtKB/TrEMBL

F7F3C3

Conserved Domains (1) summary

smart00516
Location:22 → 190

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
XM_039091558.2 → XP_038947486.1 SEC14-like protein 2 isoform X2

UniProtKB/TrEMBL

A0A8I6ADK3

Conserved Domains (2) summary

smart00516
Location:76 → 244

SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

smart01100
Location:13 → 59

CRAL_TRIO_N; CRAL/TRIO, N-terminal domain