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Kcnk4 potassium two pore domain channel subfamily K member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116489, updated on 28-Oct-2024

Summary

Official Symbol
Kcnk4provided by RGD
Official Full Name
potassium two pore domain channel subfamily K member 4provided by RGD
Primary source
RGD:621449
See related
EnsemblRapid:ENSRNOG00000021140 AllianceGenome:RGD:621449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
KT4.1; TRAAK
Summary
Enables mechanosensitive potassium channel activity; potassium ion leak channel activity; and temperature-gated cation channel activity. Involved in several processes, including cellular response to alkaline pH; cellular response to temperature stimulus; and detection of mechanical stimulus involved in sensory perception of touch. Located in node of Ranvier and plasma membrane. Orthologous to human KCNK4 (potassium two pore domain channel subfamily K member 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 34.5), Testes (RPKM 4.2) and 1 other tissue See more
Orthologs
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Genomic context

See Kcnk4 in Genome Data Viewer
Location:
1q43
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213547577..213558706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204117941..204129494, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222182997..222192139, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase activator subunit 11-2 Neighboring gene estrogen related receptor, alpha Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene uncharacterized LOC134483962 Neighboring gene G protein-coupled receptor 137 Neighboring gene BCL2-associated agonist of cell death

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mechanosensitive potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mechanosensitive potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables outward rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium ion leak channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables potassium ion leak channel activity ISO
Inferred from Sequence Orthology
more info
 
enables temperature-gated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to acidic pH ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to alkaline pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to arachidonate ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to arachidonate ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to fatty acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to mechanical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to temperature stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of touch ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of touch ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ultrasound ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ultrasound ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sensory perception of temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 4
Names
TWIK-related arachidonic acid-stimulated potassium channel protein
potassium channel, two pore domain subfamily K, member 4
potassium inwardly-rectifying channel, subfamily K, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053804.3NP_446256.3  potassium channel subfamily K member 4 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    G3V8V5, Q924I4
    Related
    ENSRNOP00000028704.1, ENSRNOT00000028704.4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    213547577..213558706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760055.4XP_008758277.1  potassium channel subfamily K member 4 isoform X2

    See identical proteins and their annotated locations for XP_008758277.1

    UniProtKB/Swiss-Prot
    G3V8V5, Q924I4
    Conserved Domains (1) summary
    pfam07885
    Location:89143
    Ion_trans_2; Ion channel
  2. XM_006230634.5XP_006230696.1  potassium channel subfamily K member 4 isoform X1

    Conserved Domains (1) summary
    pfam07885
    Location:115169
    Ion_trans_2; Ion channel
  3. XM_063263776.1XP_063119846.1  potassium channel subfamily K member 4 isoform X2

    UniProtKB/Swiss-Prot
    G3V8V5, Q924I4
  4. XM_039109360.2XP_038965288.1  potassium channel subfamily K member 4 isoform X4

    Conserved Domains (1) summary
    pfam07885
    Location:48126
    Ion_trans_2; Ion channel
  5. XM_063263854.1XP_063119924.1  potassium channel subfamily K member 4 isoform X3