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Gripap1 GRIP1 associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116493, updated on 2-Nov-2024

Summary

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Official Symbol
Gripap1provided by RGD
Official Full Name
GRIP1 associated protein 1provided by RGD
Primary source
RGD:621249
See related
EnsemblRapid:ENSRNOG00000009071 AllianceGenome:RGD:621249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Grasp1
Summary
Enables guanyl-nucleotide exchange factor activity and ionotropic glutamate receptor binding activity. Involved in negative regulation of receptor clustering; regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane; and regulation of recycling endosome localization within postsynapse. Located in dendrite; neuronal cell body; and presynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic early endosome membrane. Orthologous to human GRIPAP1 (GRIP1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 105.2), Adrenal (RPKM 78.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gripap1 in Genome Data Viewer
Location:
Xq12
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17350817..17380626, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14678896..14708747, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15523929..15553702, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 5 Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene transcription factor binding to IGHM enhancer 3 Neighboring gene small nucleolar RNA SNORA70

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons. Mele M, et al. FASEB J, 2021 Aug. PMID 34245609
  2. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. Hoogenraad CC, et al. PLoS Biol, 2010 Jan 19. PMID 20098723, Free PMC Article
  3. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. Ye B, et al. Neuron, 2000 Jun. PMID 10896157
  4. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons.
    Title: GRASP1 ubiquitination regulates AMPA receptor surface expression and synaptic activity in cultured hippocampal neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables ionotropic glutamate receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of recycling endosome localization within postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of recycling endosome localization within postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of recycling endosome localization within postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of postsynaptic early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GRIP1-associated protein 1
Names
GRASP-1
GRIP-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053807.2 → NP_446259.1  GRIP1-associated protein 1

    See identical proteins and their annotated locations for NP_446259.1

    Status: VALIDATED

    Source sequence(s)
    BQ780554, JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q9JHZ3, Q9JHZ4
    UniProtKB/TrEMBL
    A0A8I5ZRM3, A6KP79
    Related
    ENSRNOP00000012646.7, ENSRNOT00000012646.9
    Conserved Domains (2) summary
    COG1196
    Location:193 → 496
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:8 → 337
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17350817..17380626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063279751.1 → XP_063135821.1  GRIP1-associated protein 1 isoform X21

  2. XM_063279749.1 → XP_063135819.1  GRIP1-associated protein 1 isoform X19

  3. XM_063279744.1 → XP_063135814.1  GRIP1-associated protein 1 isoform X10

  4. XM_063279750.1 → XP_063135820.1  GRIP1-associated protein 1 isoform X20

  5. XM_063279747.1 → XP_063135817.1  GRIP1-associated protein 1 isoform X14

  6. XM_063279740.1 → XP_063135810.1  GRIP1-associated protein 1 isoform X4

  7. XM_063279738.1 → XP_063135808.1  GRIP1-associated protein 1 isoform X2

  8. XM_063279746.1 → XP_063135816.1  GRIP1-associated protein 1 isoform X12

  9. XM_063279742.1 → XP_063135812.1  GRIP1-associated protein 1 isoform X7

  10. XM_063279739.1 → XP_063135809.1  GRIP1-associated protein 1 isoform X3

  11. XM_063279741.1 → XP_063135811.1  GRIP1-associated protein 1 isoform X5

  12. XM_063279743.1 → XP_063135813.1  GRIP1-associated protein 1 isoform X9

  13. XM_063279737.1 → XP_063135807.1  GRIP1-associated protein 1 isoform X1

  14. XM_063279754.1 → XP_063135824.1  GRIP1-associated protein 1 isoform X24

  15. XM_063279753.1 → XP_063135823.1  GRIP1-associated protein 1 isoform X23

    Related
    ENSRNOP00000081274.1, ENSRNOT00000104859.2

  16. XM_063279745.1 → XP_063135815.1  GRIP1-associated protein 1 isoform X11

  17. XM_063279748.1 → XP_063135818.1  GRIP1-associated protein 1 isoform X16

  18. XM_063279752.1 → XP_063135822.1  GRIP1-associated protein 1 isoform X22

  19. XM_039099405.2 → XP_038955333.1  GRIP1-associated protein 1 isoform X18

    UniProtKB/TrEMBL
    A0A8I5ZRM3
    Conserved Domains (2) summary
    PTZ00121
    Location:28 → 575
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:193 → 465
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  20. XM_039099401.2 → XP_038955329.1  GRIP1-associated protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I5ZRM3
    Conserved Domains (2) summary
    PTZ00121
    Location:196 → 717
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:3 → 381
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  21. XM_039099404.2 → XP_038955332.1  GRIP1-associated protein 1 isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZRM3, A6KP78
    Related
    ENSRNOP00000085406.1, ENSRNOT00000111277.2
    Conserved Domains (1) summary
    COG1196
    Location:148 → 451
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  22. XM_039099399.2 → XP_038955327.1  GRIP1-associated protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZRM3
    Conserved Domains (2) summary
    COG1196
    Location:184 → 487
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:9 → 622
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  23. XM_039099403.2 → XP_038955331.1  GRIP1-associated protein 1 isoform X15

    UniProtKB/TrEMBL
    A0A8I5ZRM3
    Conserved Domains (1) summary
    COG1196
    Location:157 → 460
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  24. XM_039099400.2 → XP_038955328.1  GRIP1-associated protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZRM3
    Related
    ENSRNOP00000097700.2, ENSRNOT00000102832.2
    Conserved Domains (1) summary
    TIGR02168
    Location:244 → 617
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHZ4.1 GenPept UniProtKB/Swiss-Prot:Q9JHZ4

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