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Akt2 thymoma viral proto-oncogene 2 [ Mus musculus (house mouse) ]

Gene ID: 11652, updated on 2-Nov-2024

Summary

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Official Symbol
Akt2provided by MGI
Official Full Name
thymoma viral proto-oncogene 2provided by MGI
Primary source
MGI:MGI:104874
See related
Ensembl:ENSMUSG00000004056 AllianceGenome:MGI:104874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKB; PKBbeta; 2410016A19Rik
Summary
Enables protein serine/threonine kinase activity. Involved in positive regulation of protein targeting to membrane. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and insulin receptor signaling pathway. Located in cell cortex and ruffle membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and integumental system. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 40.3), mammary gland adult (RPKM 35.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Akt2 in Genome Data Viewer
Location:
7 A3; 7 15.94 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27290977..27340251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27591552..27640826)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310022A10 gene Neighboring gene predicted gene, 45975 Neighboring gene STARR-seq mESC enhancer starr_18371 Neighboring gene STARR-seq mESC enhancer starr_18372 Neighboring gene STARR-positive B cell enhancer ABC_E6525 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28376489-28376676 Neighboring gene STARR-positive B cell enhancer ABC_E11346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28377425-28377608 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18379 Neighboring gene predicted gene, 38973 Neighboring gene mitogen-activated protein kinase kinase kinase 10 Neighboring gene tetratricopeptide repeat domain 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia. Yang S, et al. Int J Mol Sci, 2017 Mar 6. PMID 28272306, Free PMC Article
  2. Myocardial injury after ischemia-reperfusion in mice deficient in Akt2 is associated with increased cardiac macrophage density. Li X, et al. Am J Physiol Heart Circ Physiol, 2011 Nov. PMID 21890689, Free PMC Article
  3. Regulation of Na+/H+ exchanger in dendritic cells by Akt2. Bhandaru M, et al. Pflugers Arch, 2012 Feb. PMID 21953010
  4. Short-chain fatty acid propionate alleviates Akt2 knockout-induced myocardial contractile dysfunction. Li L, et al. Exp Diabetes Res, 2012. PMID 21960994, Free PMC Article
  5. Characterization of the Akt2 domain essential for binding nuclear p21cip1 to promote cell cycle arrest during myogenic differentiation. Heron-Milhavet L, et al. PLoS One, 2013. PMID 24194853, Free PMC Article

See all (357) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2.
    Title: MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy by Targeting AKT2.
  2. Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes.
    Title: Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting early diabetes.
  3. Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.
    Title: Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism boosts hepatosteatosis and cancer.
  4. Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
    Title: Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity.
  5. CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.
    Title: CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.
  6. Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.
    Title: Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.
  7. Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
    Title: Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.
  8. Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
    Title: Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
  9. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.
    Title: Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis.
  10. AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
    Title: AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
Submit: New GeneRIF Correction See all GeneRIFs (168)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14031

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cellular response to high light intensity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of long-chain fatty acid import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peripheral nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of D-glucose import IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cap-dependent translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell motility ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of glycogen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal rod cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in insulin-responsive compartment ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in ruffle membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RAC-beta serine/threonine-protein kinase
Names
PKB beta
RAC-PK-beta
protein kinase Akt-2
protein kinase B, beta
NP_001103678.1
NP_001318037.1
NP_001318038.1
NP_031460.1
XP_006539544.1
XP_006539545.1
XP_006539546.1
XP_030097857.1
XP_030097858.1
XP_030097859.1
XP_030097860.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110208.2 → NP_001103678.1  RAC-beta serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001103678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK028871, AK158792, BM899551, CJ159088
    Consensus CDS
    CCDS21027.1
    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Related
    ENSMUSP00000103981.3, ENSMUST00000108344.9
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  2. NM_001331108.1 → NP_001318037.1  RAC-beta serine/threonine-protein kinase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC074312, BM899551
    Consensus CDS
    CCDS21027.1
    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  3. NM_001331109.1 → NP_001318038.1  RAC-beta serine/threonine-protein kinase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK028871, BC040377, BM899551
    Consensus CDS
    CCDS21027.1
    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  4. NM_007434.4 → NP_031460.1  RAC-beta serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_031460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK028871, AK158792, BM899551, CJ152468
    Consensus CDS
    CCDS21027.1
    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Related
    ENSMUSP00000052103.6, ENSMUST00000051356.12
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    27290977..27340251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539482.3 → XP_006539545.1  RAC-beta serine/threonine-protein kinase isoform X2

    See identical proteins and their annotated locations for XP_006539545.1

    UniProtKB/TrEMBL
    F8WHG5
    Conserved Domains (2) summary
    cd05595
    Location:113 → 435
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cl17171
    Location:4 → 68
    PH-like; Pleckstrin homology-like domain

  2. XM_030241998.1 → XP_030097858.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  3. XM_030241997.2 → XP_030097857.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  4. XM_006539483.2 → XP_006539546.1  RAC-beta serine/threonine-protein kinase isoform X2

    See identical proteins and their annotated locations for XP_006539546.1

    UniProtKB/TrEMBL
    F8WHG5
    Conserved Domains (2) summary
    cd05595
    Location:113 → 435
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cl17171
    Location:4 → 68
    PH-like; Pleckstrin homology-like domain

  5. XM_030241999.1 → XP_030097859.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Related
    ENSMUSP00000103980.2, ENSMUST00000108343.8
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  6. XM_006539481.5 → XP_006539544.1  RAC-beta serine/threonine-protein kinase isoform X1

    See identical proteins and their annotated locations for XP_006539544.1

    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

  7. XM_030242000.2 → XP_030097860.1  RAC-beta serine/threonine-protein kinase isoform X1

    UniProtKB/Swiss-Prot
    Q60823
    UniProtKB/TrEMBL
    F8WHG5, Q3TY95
    Related
    ENSMUSP00000083081.5, ENSMUST00000085917.5
    Conserved Domains (2) summary
    cd05595
    Location:156 → 478
    STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)
    cd01241
    Location:4 → 111
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60823.1 GenPept UniProtKB/Swiss-Prot:Q60823

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