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MRGPRF MAS related GPR family member F [ Homo sapiens (human) ]

Gene ID: 116535, updated on 3-Apr-2024

Summary

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Official Symbol
MRGPRFprovided by HGNC
Official Full Name
MAS related GPR family member Fprovided by HGNC
Primary source
HGNC:HGNC:24828
See related
Ensembl:ENSG00000172935 MIM:607233; AllianceGenome:HGNC:24828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RTA; MRGF; GPR140; GPR168
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in nuclear membrane and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 20.4), prostate (RPKM 13.8) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69004398..69013633, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69014626..69023860, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68771866..68780714, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68671173-68671900 Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5148 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:68701479-68702678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68714105-68714968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68747435-68747944 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68762134-68762300 Neighboring gene MAS related GPR family member D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68769878-68770378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68771339-68771840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68775087-68775794 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:68775901-68777100 Neighboring gene MRGPRF antisense RNA 1 Neighboring gene uncharacterized LOC124902701 Neighboring gene uncharacterized LOC124902702 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68807523-68808024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68808025-68808524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68811813-68812480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3689 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68818804-68819378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68820529-68821102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68833413-68834165 Neighboring gene two pore segment channel 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68847233-68848432 Neighboring gene microRNA 3164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The orphan MRGPRF receptor is expressed in entero-endocrine cells of the human gut mucosa. Van Remoortel S, et al. Cell Tissue Res, 2023 Aug. PMID 37314493
  2. RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution. Ross PC, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 2109324, Free PMC Article
  3. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Dong X, et al. Cell, 2001 Sep 7. PMID 11551509
  4. Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes. Premzl M. Gene, 2014 Apr 25. PMID 24583173
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16111, FLJ29034, FLJ40998, FLJ53714, MGC21621, DKFZp586B2122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
mas-related G-protein coupled receptor member F
Names
G protein-coupled receptor MrgF
G-protein coupled receptor 140
G-protein coupled receptor 168
MAS-related GPR, member F
Mas-related G protein-coupled receptor F
mas-related G protein-coupled MRGF
mas-related gene F protein
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098515.2 → NP_001091985.1  mas-related G-protein coupled receptor member F

    See identical proteins and their annotated locations for NP_001091985.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK122669, BC016964
    Consensus CDS
    CCDS8188.1
    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A2I4R878
    Conserved Domains (1) summary
    cd15109
    Location:45 → 318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_145015.5 → NP_659452.3  mas-related G-protein coupled receptor member F

    See identical proteins and their annotated locations for NP_659452.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC016964, BP376260
    Consensus CDS
    CCDS8188.1
    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A2I4R878
    Related
    ENSP00000309782.6, ENST00000309099.7
    Conserved Domains (1) summary
    cd15109
    Location:45 → 318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    69004398..69013633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448339.2 → XP_024304107.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A2I4R878
    Conserved Domains (1) summary
    cd15109
    Location:45 → 318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017017170.2 → XP_016872659.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1
    UniProtKB/TrEMBL
    A0A2I4R878
    Conserved Domains (1) summary
    cd15109
    Location:45 → 318
    7tmA_MrgprF; mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    69014626..69023860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367607.1 → XP_054223582.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1

  2. XM_054367606.1 → XP_054223581.1  mas-related G-protein coupled receptor member F isoform X1

    UniProtKB/Swiss-Prot
    B3KV43, Q8NBK8, Q96AM1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96AM1.1 GenPept UniProtKB/Swiss-Prot:Q96AM1

Gene LinkOut

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