U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pou6f1 POU class 6 homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116545, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pou6f1provided by RGD
Official Full Name
POU class 6 homeobox 1provided by RGD
Primary source
RGD:620615
See related
EnsemblRapid:ENSRNOG00000070769 AllianceGenome:RGD:620615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Brn5
Summary
Enables DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton and nuclear body. Orthologous to human POU6F1 (POU class 6 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 35.1), Kidney (RPKM 25.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pou6f1 in Genome Data Viewer
Location:
7q36
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133556506..133580004, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131677719..131700869, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142201614..142225256, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene transcription factor CP2 Neighboring gene uncharacterized LOC120093736 Neighboring gene uncharacterized LOC134479579 Neighboring gene uncharacterized LOC134479580

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts. Li WY, et al. J Neural Eng, 2022 Nov 10. PMID 36317259
  2. Expression of the POU transcription factor Brn-5 is an early event in the terminal differentiation of CNS neurons. Cui H, et al. J Neurosci Res, 1998 Jun 15. PMID 9669311
  3. Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex. Andersen B, et al. J Biol Chem, 1993 Nov 5. PMID 7901208
  4. Identification of novel DNA binding sites recognized by the transcription factor mPOU (POU6F1). Wey E, et al. Biochem Biophys Res Commun, 1996 Mar 18. PMID 8645295
  5. Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL. Toda K, et al. Mol Cell Endocrinol, 2008 Jan 2. PMID 17933456

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts.
    Title: Transgenic Schwann cells overexpressing POU6F1 promote sciatic nerve regeneration within acellular nerve allografts.
  2. Brn-5 enhances prolactin gene expression directly in association with Pit-1 and CREB-binding protein, and indirectly via the activation of Pit-1 gene expression.
    Title: Involvement of mPOU (Brn-5), a class VI POU protein, in the gene expression of Pit-1 as well as PRL.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
POU domain, class 6, transcription factor 1
Names
brain-5
brain-specific homeobox/POU domain protein 5
brn-5 protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105746.1 → NP_001099216.1  POU domain, class 6, transcription factor 1

    See identical proteins and their annotated locations for NP_001099216.1

    Status: VALIDATED

    Source sequence(s)
    CH474035
    UniProtKB/Swiss-Prot
    P56223
    UniProtKB/TrEMBL
    A6KCK3
    Conserved Domains (3) summary
    PRK14950
    Location:23 → 155
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam00046
    Location:237 → 291
    Homeobox; Homeobox domain
    cl22952
    Location:139 → 213
    Pou; Pou domain - N-terminal to homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133556506..133580004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078246.2 → XP_038934174.1  POU domain, class 6, transcription factor 1 isoform X3

    Conserved Domains (3) summary
    smart00352
    Location:449 → 523
    POU; Found in Pit-Oct-Unc transcription factors
    PHA03247
    Location:41 → 426
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:547 → 601
    Homeobox; Homeobox domain

  2. XM_039078243.2 → XP_038934171.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:453 → 527
    POU; Found in Pit-Oct-Unc transcription factors
    PHA03247
    Location:45 → 430
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:551 → 605
    Homeobox; Homeobox domain

  3. XM_039078244.2 → XP_038934172.1  POU domain, class 6, transcription factor 1 isoform X1

    Conserved Domains (3) summary
    smart00352
    Location:453 → 527
    POU; Found in Pit-Oct-Unc transcription factors
    PHA03247
    Location:45 → 430
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:551 → 605
    Homeobox; Homeobox domain

  4. XM_039078245.2 → XP_038934173.1  POU domain, class 6, transcription factor 1 isoform X2

    Related
    ENSRNOP00000080135.2, ENSRNOT00000100238.3
    Conserved Domains (3) summary
    smart00352
    Location:452 → 526
    POU; Found in Pit-Oct-Unc transcription factors
    PHA03247
    Location:52 → 429
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:550 → 604
    Homeobox; Homeobox domain

  5. XM_063262865.1 → XP_063118935.1  POU domain, class 6, transcription factor 1 isoform X3

  6. XM_063262864.1 → XP_063118934.1  POU domain, class 6, transcription factor 1 isoform X1

  7. XM_039078248.2 → XP_038934176.1  POU domain, class 6, transcription factor 1 isoform X6

    Conserved Domains (3) summary
    smart00352
    Location:415 → 489
    POU; Found in Pit-Oct-Unc transcription factors
    PHA03247
    Location:49 → 392
    PHA03247; large tegument protein UL36; Provisional
    pfam00046
    Location:513 → 567
    Homeobox; Homeobox domain

  8. XM_063262866.1 → XP_063118936.1  POU domain, class 6, transcription factor 1 isoform X7

  9. XM_017594569.3 → XP_017450058.1  POU domain, class 6, transcription factor 1 isoform X5

    UniProtKB/Swiss-Prot
    P56223
    UniProtKB/TrEMBL
    A6KCK3
    Conserved Domains (3) summary
    PRK14950
    Location:23 → 155
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam00046
    Location:237 → 291
    Homeobox; Homeobox domain
    cl22952
    Location:139 → 213
    Pou; Pou domain - N-terminal to homeobox domain

  10. XM_039078247.2 → XP_038934175.1  POU domain, class 6, transcription factor 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:63 → 309
    PHA03247; large tegument protein UL36; Provisional
    PRK07994
    Location:175 → 277
    PRK07994; DNA polymerase III subunits gamma and tau; Validated

RNA

  1. XR_010052928.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56223.1 GenPept UniProtKB/Swiss-Prot:P56223

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools