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Ap2m1 adaptor related protein complex 2 subunit mu 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116563, updated on 10-Jul-2024

Summary

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Official Symbol
Ap2m1provided by RGD
Official Full Name
adaptor related protein complex 2 subunit mu 1provided by RGD
Primary source
RGD:620135
See related
EnsemblRapid:ENSRNOG00000001709 AllianceGenome:RGD:620135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
mu2; Ap50; Clapm1
Summary
Enables low-density lipoprotein particle receptor binding activity and signal sequence binding activity. Involved in positive regulation of endocytosis; protein-containing complex assembly; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of AP-2 adaptor complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 970.7), Kidney (RPKM 625.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ap2m1 in Genome Data Viewer
Location:
11q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (93859690..93868600, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (80355307..80364218, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (84041184..84047542, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene microRNA 1224 Neighboring gene von Willebrand factor A domain containing 5B2 Neighboring gene uncharacterized LOC102551647 Neighboring gene ATP binding cassette subfamily F member 3 Neighboring gene uncharacterized LOC102551795 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene eukaryotic translation initiation factor 2B subunit epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons. Kyung JW, et al. Sci Rep, 2017 Jan 31. PMID 28139716, Free PMC Article
  2. A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis. Kim SH, et al. J Biol Chem, 2009 Nov 20. PMID 19762466, Free PMC Article
  3. Synaptic vesicle recycling at CNS snapses without AP-2. Kim SH, et al. J Neurosci, 2009 Mar 25. PMID 19321783, Free PMC Article
  4. Molecular cloning and complete amino acid sequence of AP50, an assembly protein associated with clathrin-coated vesicles. Thurieau C, et al. DNA, 1988 Dec. PMID 3148444
  5. The phosphorylation of coated membrane proteins in intact neurons. Keen JH, et al. J Cell Biol, 1986 Apr. PMID 2870069, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data reveal that AP-2 has important roles in functional axogenesis by proper extension of axon as well as the formation of AIS during the early step of neurodevelopment.
    Title: Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons.
  2. -2 plays a role in cargo selection but no single aspect of mu2 function is critical, implying that a more distributed network of interactions supports AP-2 function in SV endocytosis
    Title: A distributed set of interactions controls mu2 functionality in the role of AP-2 as a sorting adaptor in synaptic vesicle endocytosis.
  3. identify a gamma2-subunit-specific Yxxvarphi-type-binding motif for the clathrin adaptor protein, AP2, which is located within a site for gamma2-subunit tyrosine phosphorylation.
    Title: Regulation of synaptic inhibition by phospho-dependent binding of the AP2 complex to a YECL motif in the GABAA receptor gamma2 subunit.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC105352

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signal sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signal sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization EXP
Inferred from Experiment
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vesicle size ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle budding from membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extrinsic component of presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic endocytic zone membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton HDA PubMed 

General protein information

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Preferred Names
AP-2 complex subunit mu
Names
AP-2 mu chain
adapter-related protein complex 2 mu subunit
adapter-related protein complex 2 subunit mu
adaptor protein complex AP-2 subunit mu
adaptor-related protein complex 2 subunit mu
adaptor-related protein complex 2, mu 1 subunit
clathrin assembly protein complex 2 medium chain
clathrin assembly protein complex 2 mu medium chain
clathrin coat assembly protein AP50
clathrin coat-associated protein AP50
coat assembly protein complex 50 kD
mu2-adaptin
plasma membrane adaptor AP-2 50 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053837.2 → NP_446289.1  AP-2 complex subunit mu

    See identical proteins and their annotated locations for NP_446289.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    P84092
    UniProtKB/TrEMBL
    A0A8I5ZME4
    Related
    ENSRNOP00000054900.6, ENSRNOT00000058092.6
    Conserved Domains (2) summary
    cd09251
    Location:168 → 434
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 140
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    93859690..93868600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087902.1 → XP_038943830.1  AP-2 complex subunit mu isoform X1

    UniProtKB/TrEMBL
    A0A140TAH5, A0A8I5ZME4
    Related
    ENSRNOP00000079141.1, ENSRNOT00000100870.2
    Conserved Domains (2) summary
    cd09251
    Location:166 → 432
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
    cd14836
    Location:1 → 140
    AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

  2. XM_063270241.1 → XP_063126311.1  AP-2 complex subunit mu isoform X2

    UniProtKB/TrEMBL
    A6JSB0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84092.1 GenPept UniProtKB/Swiss-Prot:P84092

Gene LinkOut

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