Lct lactase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lctprovided by RGD
Official Full Name: lactaseprovided by RGD
Primary source: RGD:620823
See related: EnsemblRapid:ENSRNOG00000003681 AllianceGenome:RGD:620823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lph
Summary: Enables hydrolase activity, hydrolyzing O-glycosyl compounds and transferase activity. Involved in several processes, including disaccharide catabolic process; glycosylceramide catabolic process; and response to estrogen. Located in brush border. Used to study diarrhea. Biomarker of colitis. Human ortholog(s) of this gene implicated in congenital lactase deficiency. Orthologous to human LCT (lactase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 1.5), Uterus (RPKM 1.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (42334347..42376872, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (39781929..39824456, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (44998414..45040593, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest the role of these hormones in inducing changes in lactase glycosylation during postnatal development of intestine, which may contribute to adult-type hypolactasia in rats.
Title: Hormone induced changes in lactase glycosylation in developing rat intestine.
Thyroxine, insulin or cortisone induced changes in lactase expression in suckling rat intestine.
Title: Hormone induced expression of brush border lactase in suckling rat intestine.
role of promoter in regulating intestine-specific spatiotemporal expression
Title: Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter.
the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH.
Title: Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter.
results indicate that LPH may play an important role in the bioavailability of pyridoxine-5'-beta-D-glucoside (PNG)
Title: Enzymatic hydrolysis of pyridoxine-5'-beta-D-glucoside is catalyzed by intestinal lactase-phlorizin hydrolase.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables beta-glucosidase activity	ISO Inferred from Sequence Orthology more info
enables beta-glucosidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cellobiose glucosidase activity	IEA Inferred from Electronic Annotation more info
enables galactosylceramidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucosylceramidase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactase activity	IDA Inferred from Direct Assay more info	PubMed
enables lactase activity	IEA Inferred from Electronic Annotation more info
enables lactase activity	ISO Inferred from Sequence Orthology more info
enables phlorizin hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables phlorizin hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phlorizin hydrolase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellobiose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in cellobiose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellobiose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycosylceramide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lactose catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lactose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lactose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in quercetin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in quercetin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in quercetin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to iron(II) ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lead ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nickel cation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in external side of apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lactase/phlorizin hydrolase

Names: lactase-glycosylceramidase; lactase-phlorizin hydrolase

NP_446293.1

EC 3.2.1.108

EC 3.2.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053841.1 → NP_446293.1 lactase/phlorizin hydrolase preproprotein

See identical proteins and their annotated locations for NP_446293.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A9CMB6, A9CMC8

Related

ENSRNOP00000004908.4, ENSRNOT00000004908.8

Conserved Domains (2) summary

pfam00232
Location:1375 → 1842

Glyco_hydro_1; Glycosyl hydrolase family 1

cl23725
Location:380 → 849

Glyco_hydro; Glycosyl hydrolases