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Opcml opioid binding protein/cell adhesion molecule-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 116597, updated on 2-Nov-2024

Summary

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Official Symbol
Opcmlprovided by RGD
Official Full Name
opioid binding protein/cell adhesion molecule-likeprovided by RGD
Primary source
RGD:620635
See related
EnsemblRapid:ENSRNOG00000023809 AllianceGenome:RGD:620635
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in cell adhesion. Is active in postsynaptic density. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 337.9), Spleen (RPKM 53.3) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Opcml in Genome Data Viewer
Location:
8q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (34451629..35562897)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (26788988..27304551)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (28842202..29967300)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480005 Neighboring gene spermatogenesis associated 19 Neighboring gene endothelial differentiation-related factor 1, pseudogene 1 Neighboring gene uncharacterized LOC120094318 Neighboring gene uncharacterized LOC134480150 Neighboring gene neurotrimin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results of this study suggested that OBCAM is responsible for controlling the cell proliferation and growth in cortical astrocytes
    Title: OBCAM, an immunoglobulin superfamily cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes.
  2. OBCAM is synthesized within the somata, attached to vasopressin neurosecretory granules, and transported to the dendrites. The subcellular localization of OBCAM is changed in an activity-dependent manner.
    Title: Dendrite-associated opioid-binding cell adhesion molecule localizes at neurosecretory granules in the hypothalamic magnocellular neurons.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
opioid-binding protein/cell adhesion molecule
Names
OBCAM
opioid-binding cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053848.2 → NP_446300.2  opioid-binding protein/cell adhesion molecule precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P32735, P32736, Q01653, Q01654
    UniProtKB/TrEMBL
    A0A8I6A2A2, A6JYE6
    Related
    ENSRNOP00000103226.1, ENSRNOT00000137975.1
    Conserved Domains (3) summary
    pfam13927
    Location:223 → 300
    Ig_3; Immunoglobulin domain
    cd00096
    Location:224 → 230
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    34451629..35562897
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264778.1 → XP_063120848.1  opioid-binding protein/cell adhesion molecule isoform X3

  2. XM_063264779.1 → XP_063120849.1  opioid-binding protein/cell adhesion molecule isoform X5

    UniProtKB/TrEMBL
    A0A0G2K657, A6JYE4
    Related
    ENSRNOP00000073684.2, ENSRNOT00000090643.3

  3. XM_063264780.1 → XP_063120850.1  opioid-binding protein/cell adhesion molecule isoform X6

  4. XM_017595412.3 → XP_017450901.1  opioid-binding protein/cell adhesion molecule isoform X1

    UniProtKB/Swiss-Prot
    P32735, P32736, Q01653, Q01654
    Conserved Domains (3) summary
    pfam13927
    Location:223 → 300
    Ig_3; Immunoglobulin domain
    cd00096
    Location:224 → 230
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain

  5. XM_017595413.3 → XP_017450902.1  opioid-binding protein/cell adhesion molecule isoform X2

    UniProtKB/Swiss-Prot
    P32735, P32736, Q01653, Q01654
    Related
    ENSRNOP00000110858.1, ENSRNOT00000157922.1
    Conserved Domains (3) summary
    pfam13927
    Location:222 → 299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain

  6. XM_017595415.3 → XP_017450904.1  opioid-binding protein/cell adhesion molecule isoform X4

    UniProtKB/Swiss-Prot
    P32735, P32736, Q01653, Q01654
    Conserved Domains (3) summary
    pfam13927
    Location:222 → 299
    Ig_3; Immunoglobulin domain
    cd00096
    Location:223 → 229
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:44 → 132
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32736.2 GenPept UniProtKB/Swiss-Prot:P32736

Gene LinkOut

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