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Pgap2 post-GPI attachment to proteins 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116675, updated on 2-Nov-2024

Summary

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Official Symbol
Pgap2provided by RGD
Official Full Name
post-GPI attachment to proteins 2provided by RGD
Primary source
RGD:619744
See related
EnsemblRapid:ENSRNOG00000020371 AllianceGenome:RGD:619744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Frag1
Summary
Involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 3. Orthologous to human PGAP2 (post-GPI attachment to proteins 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 67.1), Adrenal (RPKM 52.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pgap2 in Genome Data Viewer
Location:
1q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166003593..166030088)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156591540..156618116)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167309021..167335550)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene ras homolog family member G Neighboring gene ribosomal protein S29, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement. Lorenzi MV, et al. Proc Natl Acad Sci U S A, 1996 Aug 20. PMID 8799135, Free PMC Article
  2. PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Tashima Y, et al. Mol Biol Cell, 2006 Mar. PMID 16407401, Free PMC Article
  3. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
  4. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Ishii H, et al. Proc Natl Acad Sci U S A, 2005 Jul 5. PMID 15983387, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
post-GPI attachment to proteins factor 2
Names
FGF receptor-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053895.2 → NP_446347.2  post-GPI attachment to proteins factor 2

    See identical proteins and their annotated locations for NP_446347.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6I724
    Related
    ENSRNOP00000068251.3, ENSRNOT00000076894.3
    Conserved Domains (1) summary
    pfam10277
    Location:18 → 237
    Frag1; Frag1/DRAM/Sfk1 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    166003593..166030088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111279.2 → XP_038967207.1  post-GPI attachment to proteins factor 2 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:102 → 253
    Frag1; Frag1/DRAM/Sfk1 family

  2. XM_063265385.1 → XP_063121455.1  post-GPI attachment to proteins factor 2 isoform X8

    UniProtKB/TrEMBL
    A0A8L2QZ37

  3. XM_063265587.1 → XP_063121657.1  post-GPI attachment to proteins factor 2 isoform X13

    UniProtKB/TrEMBL
    A6I724

  4. XM_017588671.3 → XP_017444160.1  post-GPI attachment to proteins factor 2 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:102 → 253
    Frag1; Frag1/DRAM/Sfk1 family

  5. XM_063265073.1 → XP_063121143.1  post-GPI attachment to proteins factor 2 isoform X1

  6. XM_063265255.1 → XP_063121325.1  post-GPI attachment to proteins factor 2 isoform X6

  7. XM_063265142.1 → XP_063121212.1  post-GPI attachment to proteins factor 2 isoform X2

  8. XM_063265457.1 → XP_063121527.1  post-GPI attachment to proteins factor 2 isoform X10

  9. XM_063265336.1 → XP_063121406.1  post-GPI attachment to proteins factor 2 isoform X8

    UniProtKB/TrEMBL
    A0A8L2QZ37
    Related
    ENSRNOP00000052110.6, ENSRNOT00000055235.7

  10. XM_063265289.1 → XP_063121359.1  post-GPI attachment to proteins factor 2 isoform X7

  11. XM_006229837.5 → XP_006229899.1  post-GPI attachment to proteins factor 2 isoform X11

    See identical proteins and their annotated locations for XP_006229899.1

    UniProtKB/Swiss-Prot
    P70561, Q2ABP3
    Conserved Domains (1) summary
    pfam10277
    Location:18 → 241
    Frag1; Frag1/DRAM/Sfk1 family

  12. XM_006229825.5 → XP_006229887.1  post-GPI attachment to proteins factor 2 isoform X1

    Conserved Domains (1) summary
    pfam10277
    Location:102 → 253
    Frag1; Frag1/DRAM/Sfk1 family

  13. XM_006229834.5 → XP_006229896.1  post-GPI attachment to proteins factor 2 isoform X8

    UniProtKB/TrEMBL
    A0A8L2QZ37
    Conserved Domains (1) summary
    pfam10277
    Location:18 → 180
    Frag1; Frag1/DRAM/Sfk1 family

  14. XM_063265171.1 → XP_063121241.1  post-GPI attachment to proteins factor 2 isoform X3

    Related
    ENSRNOP00000101049.1, ENSRNOT00000172029.1

  15. XM_063265198.1 → XP_063121268.1  post-GPI attachment to proteins factor 2 isoform X4

  16. XM_039111474.2 → XP_038967402.1  post-GPI attachment to proteins factor 2 isoform X9

    Related
    ENSRNOP00000105018.1, ENSRNOT00000140692.1
    Conserved Domains (1) summary
    pfam10277
    Location:27 → 178
    Frag1; Frag1/DRAM/Sfk1 family

  17. XM_063265230.1 → XP_063121300.1  post-GPI attachment to proteins factor 2 isoform X5

  18. XM_063265556.1 → XP_063121626.1  post-GPI attachment to proteins factor 2 isoform X12

    UniProtKB/TrEMBL
    D4ACY7

  19. XM_063265623.1 → XP_063121693.1  post-GPI attachment to proteins factor 2 isoform X14

  20. XM_006229835.5 → XP_006229897.1  post-GPI attachment to proteins factor 2 isoform X9

    See identical proteins and their annotated locations for XP_006229897.1

    Conserved Domains (1) summary
    pfam10277
    Location:27 → 178
    Frag1; Frag1/DRAM/Sfk1 family

  21. XM_063265669.1 → XP_063121739.1  post-GPI attachment to proteins factor 2 isoform X12

    UniProtKB/TrEMBL
    D4ACY7

  22. XM_063265703.1 → XP_063121773.1  post-GPI attachment to proteins factor 2 isoform X15

  23. XM_063265742.1 → XP_063121812.1  post-GPI attachment to proteins factor 2 isoform X16

    UniProtKB/TrEMBL
    A6I731
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2ABP3.1 GenPept UniProtKB/Swiss-Prot:Q2ABP3

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