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Kcnd1 potassium voltage-gated channel subfamily D member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116695, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnd1provided by RGD
Official Full Name
potassium voltage-gated channel subfamily D member 1provided by RGD
Primary source
RGD:621364
See related
EnsemblRapid:ENSRNOG00000039544 AllianceGenome:RGD:621364
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kv4.1
Summary
Predicted to enable A-type (transient outward) potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCND1 (potassium voltage-gated channel subfamily D member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 9.6), Uterus (RPKM 7.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kcnd1 in Genome Data Viewer
Location:
Xq12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17333612..17349255, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14661688..14678745, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15506724..15520712, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Pim-2 proto-oncogene, serine/threonine kinase Neighboring gene OTU deubiquitinase 5 Neighboring gene solute carrier family 25 member 39, pseudogene 6 Neighboring gene GRIP1 associated protein 1 Neighboring gene transcription factor binding to IGHM enhancer 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation. Chiu CY, et al. Eur J Pain, 2022 Nov. PMID 36097791
  2. Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. Kim J, et al. J Physiol, 2005 Nov 15. PMID 16141270, Free PMC Article
  3. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J, et al. Neuroscience, 2010 Dec 15. PMID 20849929, Free PMC Article
  4. Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA). Isbrandt D, et al. Genomics, 2000 Mar 1. PMID 10729221
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.
    Title: K(+) channel Kv4.1 is expressed in the nociceptors/secondary nociceptive neurons and participates in pain regulation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables A-type (transient outward) potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables A-type (transient outward) potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily D member 1
Names
potassium channel, voltage gated Shal-related subfamily D, member 1
potassium voltage gated channel Shal-related family member 1
potassium voltage-gated channel, Shal-related subfamily, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105748.1 → NP_001099218.1  potassium voltage-gated channel subfamily D member 1 precursor

    See identical proteins and their annotated locations for NP_001099218.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474078
    UniProtKB/TrEMBL
    A6KP76, D3ZYK3
    Related
    ENSRNOP00000011994.1, ENSRNOT00000011994.5
    Conserved Domains (3) summary
    cl38908
    Location:6 → 143
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:185 → 417
    Ion_trans; Ion transport protein
    pfam11879
    Location:447 → 550
    DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17333612..17349255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099410.2 → XP_038955338.1  potassium voltage-gated channel subfamily D member 1 isoform X2

    Conserved Domains (2) summary
    pfam00520
    Location:3 → 154
    Ion_trans; Ion transport protein
    pfam11879
    Location:184 → 287
    DUF3399; Domain of unknown function (DUF3399)

  2. XM_039099409.2 → XP_038955337.1  potassium voltage-gated channel subfamily D member 1 isoform X1

    UniProtKB/TrEMBL
    A6KP76, D3ZYK3
    Conserved Domains (3) summary
    cl38908
    Location:6 → 143
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:185 → 417
    Ion_trans; Ion transport protein
    pfam11879
    Location:447 → 550
    DUF3399; Domain of unknown function (DUF3399)

  3. XM_063279755.1 → XP_063135825.1  potassium voltage-gated channel subfamily D member 1 isoform X1

    UniProtKB/TrEMBL
    A6KP76, D3ZYK3
Nucleotide Protein Strain
Heading Accession and Version

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