Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pik3c2gprovided by RGD
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gammaprovided by RGD
Primary source: RGD:620231
See related: EnsemblRapid:ENSRNOG00000034228 AllianceGenome:RGD:620231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRG00132
Summary: Enables 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in phosphatidylinositol-3-phosphate biosynthetic process. Located in nuclear envelope. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 93.3) and Uterus (RPKM 3.7) See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q44

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (174215527..174583378)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (172483752..172851623)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (173732196..174102502)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability. Novel action of leptin could provide an alternative therapeutic target in the management of epilepsy.
Title: Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.
By regulating PKC-/delta-dependent signals, PI3K can play a key role in the development of hepatic tolerance to hypoxia/reperfusion.
Title: Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis.
Title: Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH137861 (e-PCR)
- UniSTS:219948

AU029015 (e-PCR)
- UniSTS:111775

BE113549 (e-PCR)
- UniSTS:246699

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 1-phosphatidylinositol 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in modulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Names: PI3K-C2-gamma; PI3K-C2gamma; phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphoinositide 3-Kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; ptdIns-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma

XP_038962876.1

EC 2.7.1.137

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053923.2 → NP_446375.2 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Related

ENSRNOP00000043855.4, ENSRNOT00000041499.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

174215527..174583378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039106948.2 → XP_038962876.1 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1

UniProtKB/TrEMBL

A6IMM4, D3ZE56

Conserved Domains (6) summary

cd04012
Location:535 → 697

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cl00271
Location:712 → 879

PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

cl02484
Location:310 → 368

PI3K_rbd; PI3-kinase family, ras-binding domain

cl02563
Location:1267 → 1367

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl14603
Location:1389 → 1501

C2; C2 domain

cl21453
Location:886 → 1238

PKc_like; Protein Kinases, catalytic domain