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Kcnh6 potassium voltage-gated channel subfamily H member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116745, updated on 17-Aug-2024

Summary

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Official Symbol
Kcnh6provided by RGD
Official Full Name
potassium voltage-gated channel subfamily H member 6provided by RGD
Primary source
RGD:620304
See related
EnsemblRapid:ENSRNOG00000008078 AllianceGenome:RGD:620304
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Erg2
Summary
Enables inward rectifier potassium channel activity. Involved in potassium ion transport. Is integral component of plasma membrane. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 7.3), Adrenal (RPKM 5.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91449025..91471012)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90949240..90970746)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94207336..94228236)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095193 Neighboring gene angiotensin I converting enzyme Neighboring gene angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of cytochrome c oxidase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes. Jang SW, et al. J Neurochem, 2010 Dec. PMID 21044070, Free PMC Article
  2. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes W, et al. J Physiol, 2005 Apr 1. PMID 15677682, Free PMC Article
  3. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. Saganich MJ, et al. J Neurosci, 2001 Jul 1. PMID 11425889, Free PMC Article
  4. Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers. Wimmers S, et al. Pflugers Arch, 2001 Jan. PMID 11212207
  5. Identification of two nervous system-specific members of the erg potassium channel gene family. Shi W, et al. J Neurosci, 1997 Dec 15. PMID 9390998, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in membrane repolarization during cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 6
Names
ERG-2
Eag-related gene member 2
eag-related protein 2
ether-a-go-go-related gene potassium channel 2
ether-a-go-go-related protein 2
potassium channel, voltage gated eag related subfamily H, member 6
potassium voltage-gated channel, subfamily H (eag-related), member 6
voltage-gated potassium channel subunit Kv11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053937.1 → NP_446389.1  potassium voltage-gated channel subfamily H member 6

    See identical proteins and their annotated locations for NP_446389.1

    Status: PROVISIONAL

    Source sequence(s)
    AF016192
    UniProtKB/Swiss-Prot
    O54853
    UniProtKB/TrEMBL
    A6HJZ7, G3V720
    Related
    ENSRNOP00000010816.2, ENSRNOT00000010816.6
    Conserved Domains (6) summary
    COG0664
    Location:588 → 701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91449025..91471012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247555.5 → XP_006247617.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWV8, A6HJZ7, G3V720
    Conserved Domains (6) summary
    COG0664
    Location:588 → 701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  2. XM_039085057.2 → XP_038940985.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    Conserved Domains (2) summary
    PLN03192
    Location:259 → 698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  3. XM_039085055.2 → XP_038940983.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    Conserved Domains (2) summary
    PLN03192
    Location:259 → 698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54853.1 GenPept UniProtKB/Swiss-Prot:O54853

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