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Alox12e arachidonate lipoxygenase, epidermal [ Mus musculus (house mouse) ]

Gene ID: 11685, updated on 2-Nov-2024

Summary

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Official Symbol
Alox12eprovided by MGI
Official Full Name
arachidonate lipoxygenase, epidermalprovided by MGI
Primary source
MGI:MGI:1274790
See related
Ensembl:ENSMUSG00000018907 AllianceGenome:MGI:1274790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8-LOX; Aloxe; 12-LOX; e-LOX1; 12-LOX-e; Alox12-ps1; Alox12-ps2
Summary
Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in arachidonate metabolic process and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol and plasma membrane. Is expressed in alimentary system; hemolymphoid system; integumental system; and respiratory system. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 12.1), ovary adult (RPKM 7.2) and 3 other tissues See more
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Genomic context

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See Alox12e in Genome Data Viewer
Location:
11 B3; 11 42.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70206436..70213545, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70315610..70322720, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33048 Neighboring gene predicted gene, 40192 Neighboring gene arachidonate 15-lipoxygenase Neighboring gene STARR-seq mESC enhancer starr_29874 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29875 Neighboring gene STARR-seq mESC enhancer starr_29876 Neighboring gene proline, glutamic acid and leucine rich protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Senescence-associated tumor growth is promoted by 12-Lipoxygenase. Patil S, et al. Aging (Albany NY), 2022 Feb 14. PMID 35158337, Free PMC Article
  2. Functional expression and cellular localization of a mouse epidermal lipoxygenase. Funk CD, et al. J Biol Chem, 1996 Sep 20. PMID 8798535
  3. Murine epidermal lipoxygenase (Aloxe) encodes a 12-lipoxygenase isoform. Kinzig A, et al. FEBS Lett, 1997 Feb 3. PMID 9037187
  4. Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene. Kim E, et al. J Biol Chem, 2004 Mar 19. PMID 14711820
  5. Genomic and cDNA cloning of a novel mouse lipoxygenase gene. van Dijk KW, et al. Biochim Biophys Acta, 1995 Oct 26. PMID 7492614

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
    Title: Senescence-associated tumor growth is promoted by 12-Lipoxygenase.
  2. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
    Title: 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat.
  3. these results suggest that the MaR1/RORalpha/12-LOX autoregulatory circuit could offer potential therapeutic strategies for curing NASH.
    Title: A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.
  4. identification and characterization of a phorbol ester-responsive element
    Title: Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 12(S)-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate 12(S)-lipoxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables arachidonate 15-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables linoleate 13S-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables linoleate 13S-lipoxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arachidonate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipoxygenase pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipoxygenase pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type
Names
arachidonate (12S)-lipoxygenase, epidermal-type
arachidonate 12-lipoxygenase, epidermal
arachidonate 12-lipoxygenase, epidermal-type
e(12S)-LOX
linoleate (13S)-lipoxygenase
NP_663717.1
XP_006532097.1
XP_006532098.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145684.2 → NP_663717.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type

    See identical proteins and their annotated locations for NP_663717.1

    Status: VALIDATED

    Source sequence(s)
    AK138743, AL596096, BX630350
    Consensus CDS
    CCDS24943.1
    UniProtKB/Swiss-Prot
    P55249, Q91YW6
    UniProtKB/TrEMBL
    Q5F2E4
    Related
    ENSMUSP00000019051.3, ENSMUST00000019051.3
    Conserved Domains (2) summary
    cd01753
    Location:2 → 111
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:169 → 653
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70206436..70213545 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532035.4 → XP_006532098.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X2

    See identical proteins and their annotated locations for XP_006532098.1

    Conserved Domains (2) summary
    cd01753
    Location:35 → 143
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:193 → 685
    Lipoxygenase

  2. XM_006532034.5 → XP_006532097.1  polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type isoform X1

    See identical proteins and their annotated locations for XP_006532097.1

    Conserved Domains (2) summary
    cd01753
    Location:35 → 144
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:194 → 686
    Lipoxygenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55249.1 GenPept UniProtKB/Swiss-Prot:P55249

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