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Stim2 stromal interaction molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 116873, updated on 2-Nov-2024

Summary

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Official Symbol
Stim2provided by MGI
Official Full Name
stromal interaction molecule 2provided by MGI
Primary source
MGI:MGI:2151156
See related
Ensembl:ENSMUSG00000039156 AllianceGenome:MGI:2151156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium channel regulator activity; calcium ion binding activity; and store-operated calcium channel activity. Predicted to be involved in activation of store-operated calcium channel activity; intracellular calcium ion homeostasis; and store-operated calcium entry. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; endocrine gland; and male reproductive gland or organ. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung adult (RPKM 8.3), thymus adult (RPKM 7.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stim2 in Genome Data Viewer
Location:
5 C1; 5 29.69 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (54155865..54278399)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (53998523..54121057)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13097 Neighboring gene predicted gene, 40305 Neighboring gene predicted gene, 30601 Neighboring gene STARR-seq mESC enhancer starr_13098 Neighboring gene predicted gene, 52846 Neighboring gene STARR-seq mESC enhancer starr_13099 Neighboring gene STARR-seq mESC enhancer starr_13101 Neighboring gene STARR-seq mESC enhancer starr_13102 Neighboring gene predicted gene 10440 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity. Popugaeva E, et al. Mol Neurodegener, 2015 Aug 15. PMID 26275606, Free PMC Article
  2. STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes. Oh MR, et al. Sci Rep, 2017 Dec 20. PMID 29263348, Free PMC Article
  3. STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Yap KA, et al. Neurobiol Learn Mem, 2017 Feb. PMID 27544849
  4. Presynaptic store-operated Ca(2+) entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress. Chanaday NL, et al. Neuron, 2021 Apr 21. PMID 33711258, Free PMC Article
  5. Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Sun S, et al. Neuron, 2014 Apr 2. PMID 24698269, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
    Title: Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
  2. RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
    Title: RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
  3. Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
    Title: Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
  4. Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
    Title: Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
  5. Orai1 inhibitor STIM2beta regulates myogenesis by controlling SOCE dependent transcriptional factors.
    Title: Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors.
  6. These data indicate that STIM1 and STIM2 have differential roles in the production of IL-4, which are stimulus dependent. Furthermore, these results illustrate the vital role of STIM2 in basophils, which is often considered to be less important than STIM1.
    Title: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.
  7. mice deficient in both Stim1 and Stim2 in T cells (conditional double knockout [cDKO]) developed lymphoproliferative disorders and skin inflammation with a concomitant increase in serum IgG1 and IgE levels.
    Title: Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders.
  8. Results indicate that preformed clusters of STIM and ORAI1 enable local Ca(2+) entry events in unstimulated cells. Upon TCR activation, NAADP-evoked Ca(2+) release through RYR1, in coordination with Ca(2+) entry through ORAI1 and STIM, rapidly increases the number of Ca(2+) microdomains, thereby initiating spread of Ca(2+) signals deeper into the cytoplasm to promote full T cell activation.
    Title: ORAI1, STIM1/2, and RYR1 shape subsecond Ca(2+) microdomains upon T cell activation.
  9. data show that loss of SOCE in enamel cells has substantial detrimental effects on gene expression, cell function, and the mineralization of dental enamel
    Title: Store-operated Ca(2+) entry controls ameloblast cell function and enamel development.
  10. regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes
    Title: STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables store-operated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in activation of store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of store-operated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
stromal interaction molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081103.2 → NP_001074572.2  stromal interaction molecule 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001074572.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC139037, AK173183, BF472598
    Consensus CDS
    CCDS39089.2
    UniProtKB/Swiss-Prot
    P83093, Q69ZI3, Q80VF4
    UniProtKB/TrEMBL
    A5CVE4, B2RQE3, B7ZN44
    Related
    ENSMUSP00000113174.3, ENSMUST00000117661.9
    Conserved Domains (3) summary
    cd09574
    Location:132 → 205
    SAM_STIM2; SAM domain of STIM2 subfamily proteins
    smart00454
    Location:133 → 197
    SAM; Sterile alpha motif
    pfam16533
    Location:348 → 445
    SOAR; STIM1 Orai1-activating region

  2. NM_001363348.1 → NP_001350277.1  stromal interaction molecule 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC139037, AC158152
    Consensus CDS
    CCDS89921.1
    UniProtKB/TrEMBL
    B2RQE3, B7ZN44, I1E4X8
    Related
    ENSMUSP00000143855.2, ENSMUST00000201469.4
    Conserved Domains (3) summary
    cd09574
    Location:132 → 205
    SAM_STIM2; SAM domain of STIM2 subfamily proteins
    pfam16533
    Location:348 → 453
    SOAR; STIM1 Orai1-activating region
    cl27055
    Location:250 → 430
    MutS_III; MutS domain III

  3. NM_054083.2 → NP_473424.2  stromal interaction molecule 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC139037, AC158152, AK041804
    UniProtKB/TrEMBL
    B2RQE3, B7ZN44
    Conserved Domains (3) summary
    cd09574
    Location:132 → 205
    SAM_STIM2; SAM domain of STIM2 subfamily proteins
    pfam16533
    Location:348 → 416
    SOAR; STIM1 Orai1-activating region
    cl27055
    Location:250 → 340
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    54155865..54278399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83093.2 GenPept UniProtKB/Swiss-Prot:P83093

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