Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcns1provided by RGD
Official Full Name: potassium voltage-gated channel, modifier subfamily S, member 1provided by RGD
Primary source: RGD:621524
See related: EnsemblRapid:ENSRNOG00000013681 AllianceGenome:RGD:621524
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kv9.1
Summary: Predicted to enable potassium channel regulator activity. Predicted to be involved in action potential; potassium ion transmembrane transport; and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 17.3), Lung (RPKM 1.6) and 1 other tissue See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 3q42

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (173255028..173262432, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152835642..152843032, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160554423..160561820, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our results demonstrate that Kv9.1 dysfunction leads to spontaneous and evoked neuronal hyperexcitability in myelinated fibers, coupled with development of neuropathic pain behaviors.
Title: Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:493397

RH133749 (e-PCR)
- UniSTS:217032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: potassium voltage-gated channel subfamily S member 1

Names: K+ voltage-gated channel, subfamily S, 1; delayed-rectifier K(+) channel alpha subunit 1; potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1; voltage-gated potassium channel subunit Kv9.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053954.2 → NP_446406.1 potassium voltage-gated channel subfamily S member 1

See identical proteins and their annotated locations for NP_446406.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

O88758

UniProtKB/TrEMBL

A6JX60

Related

ENSRNOP00000018364.2, ENSRNOT00000018364.5

Conserved Domains (4) summary

smart00225
Location:23 → 125

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:238 → 439

Ion_trans; Ion transport protein

pfam02214
Location:21 → 120

BTB_2; BTB/POZ domain

pfam07885
Location:355 → 433

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

173255028..173262432 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591433.3 → XP_017446922.1 potassium voltage-gated channel subfamily S member 1 isoform X1

UniProtKB/Swiss-Prot

O88758

UniProtKB/TrEMBL

A6JX60

Conserved Domains (4) summary

smart00225
Location:23 → 125

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:238 → 439

Ion_trans; Ion transport protein

pfam02214
Location:21 → 120

BTB_2; BTB/POZ domain

pfam07885
Location:355 → 433

Ion_trans_2; Ion channel
XM_006235509.5 → XP_006235571.1 potassium voltage-gated channel subfamily S member 1 isoform X1

See identical proteins and their annotated locations for XP_006235571.1

UniProtKB/Swiss-Prot

O88758

UniProtKB/TrEMBL

A6JX60

Conserved Domains (4) summary

smart00225
Location:23 → 125

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:238 → 439

Ion_trans; Ion transport protein

pfam02214
Location:21 → 120

BTB_2; BTB/POZ domain

pfam07885
Location:355 → 433

Ion_trans_2; Ion channel