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Rraga Ras-related GTP binding A [ Rattus norvegicus (Norway rat) ]

Gene ID: 117044, updated on 2-Nov-2024

Summary

Official Symbol
Rragaprovided by RGD
Official Full Name
Ras-related GTP binding Aprovided by RGD
Primary source
RGD:619804
See related
AllianceGenome:RGD:619804
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Raga
Summary
Enables GTP binding activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP; GATOR1 complex; and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGA (Ras related GTP binding A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See Rraga in Genome Data Viewer
Location:
5q31
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (106159335..106160930)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (101113341..101114936)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (104941067..104942662)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ADAMTS-like 1 Neighboring gene stabilizer of axonemal microtubules 1 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene HAUS augmin like complex subunit 6 Neighboring gene perilipin 2

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-membrane adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-membrane adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-membrane adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in biological_process ND
No biological Data available
more info
 
involved_in cellular response to amino acid starvation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TORC1 signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to lysosome IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to lysosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to amino acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IEA
Inferred from Electronic Annotation
more info
 
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of GATOR1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of GATOR1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of GATOR1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of Gtr1-Gtr2 GTPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
ras-related GTP-binding protein A
Names
Ras-related GTP-binding protein ragA
rag A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053973.3NP_446425.1  ras-related GTP-binding protein A

    See identical proteins and their annotated locations for NP_446425.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    Q63486
    UniProtKB/TrEMBL
    A0A8L2Q4X0, A6J865
    Conserved Domains (1) summary
    cd11384
    Location:9292
    RagA_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    106159335..106160930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)