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Hivep1 HIVEP zinc finger 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117140, updated on 2-Nov-2024

Summary

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Official Symbol
Hivep1provided by RGD
Official Full Name
HIVEP zinc finger 1provided by RGD
Primary source
RGD:727847
See related
EnsemblRapid:ENSRNOG00000014460 AllianceGenome:RGD:727847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables DNA binding activity. Predicted to be involved in BMP signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; mitochondrion; and nuclear body. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 81.1), Lung (RPKM 63.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hivep1 in Genome Data Viewer
Location:
17p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (22790855..22920359, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (22585016..22714517, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22278103..22403362, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene endothelin 1 Neighboring gene uncharacterized LOC102548003 Neighboring gene uncharacterized LOC120097876 Neighboring gene uncharacterized LOC108348545 Neighboring gene uncharacterized LOC134482771 Neighboring gene uncharacterized LOC134482838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation of two cDNAs encoding zinc finger proteins which bind to the alpha 1-antitrypsin promoter and to the major histocompatibility complex class I enhancer. Mitchelmore C, et al. Nucleic Acids Res, 1991 Jan 11. PMID 1901405, Free PMC Article
  2. Cirhin up-regulates a canonical NF-kappaB element through strong interaction with Cirip/HIVEP1. Yu B, et al. Exp Cell Res, 2009 Nov 1. PMID 19732766
  3. Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang X, et al. J Biol Chem, 2005 May 13. PMID 15778499
  4. Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism. Yao LC, et al. Development, 2006 Oct. PMID 17008448
  5. The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Wissmüller S, et al. Nucleic Acids Res, 2006. PMID 16582099, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables HMG box domain binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 40
Names
human immunodeficiency virus type I enhancer binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105751.2 → NP_001099221.2  zinc finger protein 40

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J757
    Conserved Domains (4) summary
    smart00355
    Location:2100 → 2121
    ZnF_C2H2; zinc finger
    PHA03247
    Location:2272 → 2662
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2074 → 2094
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    22790855..22920359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095309.2 → XP_038951237.1  zinc finger protein 40 isoform X1

    UniProtKB/TrEMBL
    A6J757
    Conserved Domains (6) summary
    PHA03247
    Location:2273 → 2663
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2075 → 2095
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2073 → 2095
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:2101 → 2166
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  2. XM_039095308.1 → XP_038951236.1  zinc finger protein 40 isoform X1

    UniProtKB/TrEMBL
    A6J757
    Conserved Domains (6) summary
    PHA03247
    Location:2273 → 2663
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2075 → 2095
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2073 → 2095
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:2101 → 2166
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  3. XM_039095310.1 → XP_038951238.1  zinc finger protein 40 isoform X1

    UniProtKB/TrEMBL
    A6J757
    Related
    ENSRNOP00000019389.8, ENSRNOT00000019389.9
    Conserved Domains (6) summary
    PHA03247
    Location:2273 → 2663
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:409 → 429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:2075 → 2095
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:2073 → 2095
    zf-C2H2; Zinc finger, C2H2 type
    pfam12756
    Location:2101 → 2166
    zf-C2H2_2; C2H2 type zinc-finger (2 copies)
    pfam13465
    Location:422 → 446
    zf-H2C2_2; Zinc-finger double domain

  4. XM_063276029.1 → XP_063132099.1  zinc finger protein 40 isoform X2

    UniProtKB/TrEMBL
    F1M9H4

  5. XM_063276031.1 → XP_063132101.1  zinc finger protein 40 isoform X4

  6. XM_063276030.1 → XP_063132100.1  zinc finger protein 40 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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