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Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [ Mus musculus (house mouse) ]

Gene ID: 117150, updated on 28-Oct-2024

Summary

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Official Symbol
Pip4k2cprovided by MGI
Official Full Name
phosphatidylinositol-5-phosphate 4-kinase, type II, gammaprovided by MGI
Primary source
MGI:MGI:2152214
See related
Ensembl:ENSMUSG00000025417 AllianceGenome:MGI:2152214
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pip5k2c
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and identical protein binding activity. Predicted to be involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Predicted to be located in autophagosome; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 43.6), genital fat pad adult (RPKM 30.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pip4k2c in Genome Data Viewer
Location:
10 D3; 10 74.5 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127032936..127047508, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127197067..127211628, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene deltex 3, E3 ubiquitin ligase Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene STARR-positive B cell enhancer ABC_E9810 Neighboring gene predicted gene, 40800 Neighboring gene dynactin 2 Neighboring gene methyl-CpG binding domain protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart. Magadum A, et al. Adv Sci (Weinh), 2021 May. PMID 34026458, Free PMC Article
  2. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Shim H, et al. Proc Natl Acad Sci U S A, 2016 Jul 5. PMID 27313209, Free PMC Article
  3. Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron. Clarke JH, et al. Am J Physiol Renal Physiol, 2008 Nov. PMID 18753295, Free PMC Article
  4. Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain. Clarke JH, et al. J Comp Neurol, 2009 Nov 20. PMID 19757494, Free PMC Article
  5. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c. Cao X, et al. G3 (Bethesda), 2023 Aug 9. PMID 36691351, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
    Title: Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c.
  2. Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
    Title: Therapeutic Delivery of Pip4k2c-Modified mRNA Attenuates Cardiac Hypertrophy and Fibrosis in the Failing Heart.
  3. PI5P4Kgamma plays a role in the regulation of the immune system via mTORC1 signaling.
    Title: Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system.
  4. our data suggest that PIP4Kgamma may have a role in neuron function, specifically in the regulation of vesicular transport, in specific regions of the developed brain
    Title: Distribution and neuronal expression of phosphatidylinositol phosphate kinase IIgamma in the mouse brain.
  5. PIP4Kgamma may have a function in the regulation of vesicular transport in specialized kidney epithelial cells.
    Title: Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Names
PI(5)P 4-kinase type II gamma
PIP4KII-gamma
phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
NP_001346209.1
NP_473438.1
XP_006513184.1
XP_011241590.1
XP_011241591.1
XP_036011413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359280.1 → NP_001346209.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    Status: VALIDATED

    Source sequence(s)
    AB054591, AC144852, BB856667, BP766151
    Consensus CDS
    CCDS24232.1
    UniProtKB/Swiss-Prot
    Q3UFU5, Q91XU3, Q99K02
    Conserved Domains (1) summary
    cd17311
    Location:46 → 418
    PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

  2. NM_054097.3 → NP_473438.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

    See identical proteins and their annotated locations for NP_473438.1

    Status: VALIDATED

    Source sequence(s)
    AB054591, AC144852, BB856667
    Consensus CDS
    CCDS24232.1
    UniProtKB/Swiss-Prot
    Q3UFU5, Q91XU3, Q99K02
    Related
    ENSMUSP00000013970.8, ENSMUST00000013970.9
    Conserved Domains (1) summary
    cd17311
    Location:46 → 418
    PIPKc_PIP5K2C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP5K2C) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127032936..127047508 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243289.4 → XP_011241591.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X3

    Conserved Domains (1) summary
    cl28923
    Location:46 → 291
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  2. XM_011243288.4 → XP_011241590.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1

    Conserved Domains (1) summary
    cl28923
    Location:117 → 349
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  3. XM_006513121.5 → XP_006513184.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

    See identical proteins and their annotated locations for XP_006513184.1

    Conserved Domains (1) summary
    cl28923
    Location:117 → 476
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  4. XM_036155520.1 → XP_036011413.1  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X2

    Conserved Domains (1) summary
    cl28923
    Location:117 → 476
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

RNA

  1. XR_871695.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XU3.1 GenPept UniProtKB/Swiss-Prot:Q91XU3

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