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Pop5 POP5 homolog, ribonuclease P/MRP subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 117241, updated on 17-Aug-2024

Summary

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Official Symbol
Pop5provided by RGD
Official Full Name
POP5 homolog, ribonuclease P/MRP subunitprovided by RGD
Primary source
RGD:1311819
See related
EnsemblRapid:ENSRNOG00000001199 AllianceGenome:RGD:1311819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
rpP2; Rnasep3
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in rRNA processing and tRNA 5'-leader removal. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 141.3), Heart (RPKM 88.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pop5 in Genome Data Viewer
Location:
12q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47037451..47045778, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41376755..41384882, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47138346..47143152, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096006 Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ring finger protein 10 Neighboring gene calcium binding protein 1 Neighboring gene uncharacterized LOC134481303 Neighboring gene uncharacterized LOC102548245

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
  2. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648
  3. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. van Eenennaam H, et al. J Biol Chem, 2001 Aug 24. PMID 11413139
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease P/MRP protein subunit POP5
Names
processing of precursor 5, ribonuclease P/MRP family
processing of precursor 5, ribonuclease P/MRP subunit
ribonuclease P protein 3
NP_001099222.2
XP_017453738.1
XP_063127091.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105752.2 → NP_001099222.2  ribonuclease P/MRP protein subunit POP5

    See identical proteins and their annotated locations for NP_001099222.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J1W0, A6J1W1, D3ZY31
    Related
    ENSRNOP00000001591.6, ENSRNOT00000001591.9
    Conserved Domains (1) summary
    pfam01900
    Location:7 → 115
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47037451..47045778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598249.3 → XP_017453738.1  ribonuclease P/MRP protein subunit POP5 isoform X1

    UniProtKB/TrEMBL
    A6J1W0, A6J1W1, D3ZY31
    Conserved Domains (1) summary
    pfam01900
    Location:7 → 115
    RNase_P_Rpp14; Rpp14/Pop5 family

  2. XM_063271021.1 → XP_063127091.1  ribonuclease P/MRP protein subunit POP5 isoform X1

    UniProtKB/TrEMBL
    A6J1W0, A6J1W1, D3ZY31
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials