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Acsl6 acyl-CoA synthetase long-chain family member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117243, updated on 28-Oct-2024

Summary

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Official Symbol
Acsl6provided by RGD
Official Full Name
acyl-CoA synthetase long-chain family member 6provided by RGD
Primary source
RGD:69403
See related
EnsemblRapid:ENSRNOG00000026745 AllianceGenome:RGD:69403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Facl6; Lacsl
Summary
Enables arachidonate-CoA ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum membrane; mitochondrial outer membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 283.1), Muscle (RPKM 230.5) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acsl6 in Genome Data Viewer
Location:
10q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38940668..38999515)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (38439914..38501182)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (39654771..39717592)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene colony stimulating factor 2 Neighboring gene interleukin 3 Neighboring gene uncharacterized LOC120095100 Neighboring gene uncharacterized LOC120095099 Neighboring gene meiotic kinetochore factor Neighboring gene U6 spliceosomal RNA Neighboring gene folliculin interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. Marszalek JR, et al. J Biol Chem, 2005 Mar 18. PMID 15655248
  2. Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Van Horn CG, et al. Biochemistry, 2005 Feb 8. PMID 15683247
  3. Cloning and functional expression of a novel long-chain acyl-CoA synthetase expressed in brain. Fujino T, et al. J Biochem, 1992 Feb. PMID 1569043
  4. Transient maintenance in bioreactor improves health of neuronal cells. Di Loreto S, et al. In Vitro Cell Dev Biol Anim, 2006 May-Jun. PMID 16848632
  5. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Dillon JS, et al. Diabetes, 2000 Dec. PMID 11118002

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
    Title: Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro.
  2. ACSL6 drives acyl-CoA toward lipid synthesis and its downregulation improves mitochondrial biogenesis, respiratory capacity and lipid oxidation
    Title: Long-chain acyl-CoA synthetase 6 regulates lipid synthesis and mitochondrial oxidative capacity in human and rat skeletal muscle.
  3. variations in the ACSL6 gene may contribute to the quantity of cigarettes smoked
    Title: ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure.
  4. Acsl6 functions primarily in DHA metabolism, and its overexpression increases DHA and AA internalization primarily during the first 24 h of neuronal differentiation to stimulate phospholipid synthesis and enhance neurite outgrowth
    Title: Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism.
  5. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
    Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in fatty acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in long-chain fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in phospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of long-chain fatty acid import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to gravity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to steroid hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in triglyceride biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in very long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 6
Names
LACS 6
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 6
long-chain acyl-CoA synthetase 6
long-chain-fatty-acid--CoA ligase, brain isozyme
NP_570095.2
XP_006246283.3
XP_006246284.3
XP_006246286.1
XP_038941005.2
XP_063124393.1
XP_063124394.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130739.2 → NP_570095.2  long-chain-fatty-acid--CoA ligase 6

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P33124, Q63835, Q6IU14
    UniProtKB/TrEMBL
    A0A0A6YYM0, A6HEH5
    Related
    ENSRNOP00000033248.6, ENSRNOT00000030760.6
    Conserved Domains (1) summary
    cd05927
    Location:116 → 694
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    38940668..38999515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246224.5 → XP_006246286.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

    See identical proteins and their annotated locations for XP_006246286.1

    UniProtKB/TrEMBL
    A0A8I5ZSH7
    Related
    ENSRNOP00000081838.1, ENSRNOT00000115137.2
    Conserved Domains (2) summary
    PLN02736
    Location:79 → 694
    PLN02736; long-chain acyl-CoA synthetase
    cd05927
    Location:116 → 693
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. XM_006246221.5 → XP_006246283.3  long-chain-fatty-acid--CoA ligase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I6B3S2
    Related
    ENSRNOP00000096136.1, ENSRNOT00000103397.2

  3. XM_006246222.5 → XP_006246284.3  long-chain-fatty-acid--CoA ligase 6 isoform X1

    Related
    ENSRNOP00000055608.6, ENSRNOT00000058817.7

  4. XM_063268324.1 → XP_063124394.1  long-chain-fatty-acid--CoA ligase 6 isoform X6

  5. XM_039085077.2 → XP_038941005.2  long-chain-fatty-acid--CoA ligase 6 isoform X3

  6. XM_063268323.1 → XP_063124393.1  long-chain-fatty-acid--CoA ligase 6 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33124.1 GenPept UniProtKB/Swiss-Prot:P33124

Gene LinkOut

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