Prdx1 peroxiredoxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prdx1provided by RGD
Official Full Name: peroxiredoxin 1provided by RGD
Primary source: RGD:620039
See related: EnsemblRapid:ENSRNOG00000017194 AllianceGenome:RGD:620039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hbp23
Summary: Enables heme binding activity; identical protein binding activity; and peroxiredoxin activity. Involved in response to oxidative stress. Located in several cellular components, including euchromatin; mitochondrial matrix; and peroxisomal matrix. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 5478.8), Kidney (RPKM 3636.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q35

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (135383906..135399504)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (130147258..130162856)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (135536413..135551986)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model.
Title: Silencing of peroxiredoxin 1 expression ameliorates ulcerative colitis in a rat model.
Pancreatic beta-cells use cytoplasmic Prdx1 as a primary defense mechanism against both ROS and RNS.
Title: Peroxiredoxin 1 plays a primary role in protecting pancreatic β-cells from hydrogen peroxide and peroxynitrite.
Prdx1 inhibited MAPK pathway induced cells apoptosis, and reactive oxygen species is the upstream regulator of hypoxia/reoxygenation induced apoptosis.
Title: Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury.
peroxiredoxin 1 has a role in redox sensing and transducing [review]
Title: The role of peroxiredoxin 1 in redox sensing and transducing.
TLR4 silencing inhibits the peroxiredocin 1 -induced proliferation of vascular smooth muscle cells.
Title: Prx1 promotes the proliferation and migration of vascular smooth muscle cells in a TLR4-dependent manner.
Increased expression of Prdx1 was identified in astrocytes and microglia following traumatic spinal cord injury.
Title: Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats.
Prx1 may alleviate renal tubulointerstitial fibrosis by inhibiting oxidative stress induced apoptosis via p38 MAPK pathway.
Title: Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis.
Prdx 1 expression increased during late gestation & peaked at postnatal-day 1, when its expression gradually decreased. It was strongly expressed in the corpus callosum.
Title: Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
X-ray diffraction analysis showed HBP23/Prx I has a Cys(83)-Cys(83) disulfide bond at only one dimer-dimer interface, whereas the interactions at the other interfaces appear to involve hydrophobic and van der Waals forces.
Title: Dimer-oligomer interconversion of wild-type and mutant rat 2-Cys peroxiredoxin: disulfide formation at dimer-dimer interfaces is not essential for decamerization.
overexpression of PRX1 protected cells against 6-OHDA-induced activation of p38 MAPK and subsequent activation of caspase-3.
Title: Oxidative modification of peroxiredoxin is associated with drug-induced apoptotic signaling in experimental models of Parkinson disease.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127925 (e-PCR)
- UniSTS:211235

Prdx1 (e-PCR), detects polymorphism
- UniSTS:259380

Prdx1 (e-PCR), detects polymorphism
- UniSTS:166199

UniSTS:470676 (e-PCR)
- UniSTS:470676

Prdx1 (e-PCR), detects polymorphism
- UniSTS:470676

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_negative_effect canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within erythrocyte homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in removal of superoxide radicals	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to reactive oxygen species	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: peroxiredoxin-1

Names: heme-binding 23 kDa protein; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1

NP_476455.1

EC 1.11.1.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057114.3 → NP_476455.1 peroxiredoxin-1

See identical proteins and their annotated locations for NP_476455.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

Q63716

UniProtKB/TrEMBL

A6JZ89

Related

ENSRNOP00000023132.2, ENSRNOT00000023132.7

Conserved Domains (1) summary

cd03015
Location:8 → 180

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...