U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tra2b transformer 2 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 117259, updated on 28-Oct-2024

Summary

Official Symbol
Tra2bprovided by RGD
Official Full Name
transformer 2 betaprovided by RGD
Primary source
RGD:619886
See related
EnsemblRapid:ENSRNOG00000001783 AllianceGenome:RGD:619886
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs10; Srsf10
Summary
Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in response to reactive oxygen species. Located in perinuclear region of cytoplasm. Orthologous to human TRA2B (transformer 2 beta homolog). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 422.3), Spleen (RPKM 311.7) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tra2b in Genome Data Viewer
Location:
11q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (92293403..92311651)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (78788880..78807252)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (82373828..82392208)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene proteasome activator subunit 3, pseudogene 4 Neighboring gene ribosomal protein L27A like 7 Neighboring gene insulin-like growth factor 2 mRNA binding protein 2 Neighboring gene uncharacterized LOC134481028 Neighboring gene SUMO specific peptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables pre-mRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex regionalization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebral cortex regionalization ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic brain development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of RNA splicing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to reactive oxygen species IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transformer-2 protein homolog beta
Names
RA301
TRA-2 beta
TRA2-beta
serine/arginine-rich splicing factor 10
splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)
transformer 2 beta homolog
transformer-2 protein homolog B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057119.1NP_476460.1  transformer-2 protein homolog beta

    See identical proteins and their annotated locations for NP_476460.1

    Status: PROVISIONAL

    Source sequence(s)
    D49708
    UniProtKB/Swiss-Prot
    P62997
    UniProtKB/TrEMBL
    A6JS59
    Related
    ENSRNOP00000095605.2, ENSRNOT00000102904.2
    Conserved Domains (1) summary
    cd12363
    Location:117196
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    92293403..92311651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248536.5XP_006248598.1  transformer-2 protein homolog beta isoform X1

    See identical proteins and their annotated locations for XP_006248598.1

    Conserved Domains (1) summary
    cd12363
    Location:117196
    RRM_TRA2; RNA recognition motif (RRM) found in transformer-2 protein homolog TRA2-alpha, TRA2-beta and similar proteins
  2. XM_063270247.1XP_063126317.1  transformer-2 protein homolog beta isoform X2

    UniProtKB/TrEMBL
    A0A8I6B318
    Related
    ENSRNOP00000076861.2, ENSRNOT00000105364.2