Rps6ka2 ribosomal protein S6 kinase A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rps6ka2provided by RGD
Official Full Name: ribosomal protein S6 kinase A2provided by RGD
Primary source: RGD:620676
See related: EnsemblRapid:ENSRNOG00000013194 AllianceGenome:RGD:620676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein serine/threonine/tyrosine kinase activity and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Predicted to be located in meiotic spindle and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 261.6), Heart (RPKM 95.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (55178988..55454271)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (52631582..52906739)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (53219346..53499445)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Anchored RSK3 transduces signals that modulate pathologic myocyte growth in cardiac hypertrophy.
Title: Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte hypertrophy.
These findings suggest that nicotinamide protects neuronal cells against cerebral ischemic injury and that MEK-ERK-p90RSK cascade activation by nicotinamide contributes to these neuroprotective effects.
Title: Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury.
Data show that p90RSK is over-expressed in activated hepatic stellate cells (HSCs) and is involved in regulating the abnormal expression of collagen type I through initiating the proliferation of HSCs.
Title: Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis.
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
Title: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF386574 (e-PCR)
- UniSTS:243776

BE096506 (e-PCR)
- UniSTS:244034

RH127829 (e-PCR)
- UniSTS:211139

D1Rat489 (e-PCR), detects polymorphism
- UniSTS:227270

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribosomal protein S6 kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within brain renin-angiotensin system	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to carbohydrate stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-2

Names: ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2

NP_476469.1

EC 2.7.11.1

XP_038934903.1

EC 2.7.11.1

XP_038934949.1

EC 2.7.11.1

XP_038934984.1

EC 2.7.11.1

XP_038935050.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057128.1 → NP_476469.1 ribosomal protein S6 kinase alpha-2

See identical proteins and their annotated locations for NP_476469.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GEE6, A6KK46, F1M7N7

Related

ENSRNOP00000017809.5, ENSRNOT00000017809.7

Conserved Domains (4) summary

smart00220
Location:59 → 318

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:63 → 379

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:411 → 703

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)

pfam00069
Location:415 → 672

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

55178988..55454271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078975.2 → XP_038934903.1 ribosomal protein S6 kinase alpha-2 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0U0, A0A8I6AWJ2

Related

ENSRNOP00000097579.1, ENSRNOT00000103591.2

Conserved Domains (2) summary

cd05582
Location:92 → 408

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:440 → 732

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
XM_039079021.2 → XP_038934949.1 ribosomal protein S6 kinase alpha-2 isoform X2

UniProtKB/TrEMBL

A0A8I5Y0U0, A0A8I5ZYL5

Related

ENSRNOP00000084178.1, ENSRNOT00000107274.2

Conserved Domains (2) summary

cd05582
Location:65 → 381

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:413 → 705

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
XM_039079056.2 → XP_038934984.1 ribosomal protein S6 kinase alpha-2 isoform X3

UniProtKB/TrEMBL

A0A8I6A7B5, A0A8I6GEE6

Related

ENSRNOP00000088182.1, ENSRNOT00000095647.2

Conserved Domains (2) summary

cd05582
Location:47 → 363

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:395 → 687

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)
XM_039079122.2 → XP_038935050.1 ribosomal protein S6 kinase alpha-2 isoform X4

UniProtKB/TrEMBL

A0A8I5Y0U0

Conserved Domains (2) summary

cd05582
Location:1 → 290

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14178
Location:322 → 614

STKc_RSK3_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2)