Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a4provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4provided by MGI
Primary source: MGI:MGI:1353495
See related: Ensembl:ENSMUSG00000031633 AllianceGenome:MGI:1353495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ant1; mANC1
Summary: Enables ATP:ADP antiporter activity; oxidative phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including nucleotide transmembrane transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 2616.6), cerebellum adult (RPKM 363.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.22 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (46660205..46664099, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (46207168..46211062, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster.
Title: Single-cell transcriptomics in MI identify Slc25a4 as a new modulator of mitochondrial malfunction and apoptosis-associated cardiomyocyte subcluster.
The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Title: The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).
Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
Title: Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
Identification of ADP/ATP Translocase 1 as a Novel Glycoprotein and Its Association with Parkinson's Disease.
Title: Identification of ADP/ATP Translocase 1 as a Novel Glycoprotein and Its Association with Parkinson's Disease.
Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice.
Title: Nicotinamide riboside alleviates exercise intolerance in ANT1-deficient mice.
Mice that lack ANT1 show blunted mitophagy and consequent profound accumulation of aberrant mitochondria
Title: The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
By mediating two distinct transport modes, ADP/ATP exchange and H(+) leak, ADP/ATP carrier connects coupled (ATP production) and uncoupled (thermogenesis) energy conversion in mitochondria.
Title: H(+) transport is an integral function of the mitochondrial ADP/ATP carrier.
Results suggest that adenine nucleotide translocator 1 (ANT1) modulates interleukin-6 (IL-6) expression through JNK signal pathway in macrophages.
Title: The inner mitochondrial membrane protein ANT1 modulates IL-6 expression via the JNK pathway in macrophages.
The ANT1-deficient muscle mitochondria produce excess reactive oxygen species (ROS) and are partially uncoupled. Hence, the muscle respiration under nonphosphorylating conditions is increased. Muscle transcriptome analysis revealed the induction of mitochondrial biogenesis, down-regulation of diabetes-related genes, and increased expression of the genes encoding the myokines FGF21 and GDF15.
Title: Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity.
ANT1 can induce autoimmune myocarditis in A/J mice by generating autoreactive T cells.
Title: Identification of an Epitope from Adenine Nucleotide Translocator 1 That Induces Inflammation in Heart in A/J Mice.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Nutf2 (e-PCR), detects polymorphism
- UniSTS:141080

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141081

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141082

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141083

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:141084

RH136547 (e-PCR)
- UniSTS:210529

SHGC-59516 (e-PCR)
- UniSTS:63975

Slc25a4 (e-PCR), detects polymorphism
- UniSTS:547055

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP:ADP antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP:ADP antiporter activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables oxidative phosphorylation uncoupler activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ADP transport	ISO Inferred from Sequence Orthology more info
involved_in ADP transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic mitochondrial changes	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial ADP transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial ADP transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ADP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial ATP transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial ATP transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ATP transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of necroptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial permeability transition pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed

General protein information

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Preferred Names: ADP/ATP translocase 1

Names: ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle; ANT 1; adenine nucleotide translocase-1; adenine nucleotide translocator 1, skeletal muscle; solute carrier family 25 member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.