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Uba3 ubiquitin-like modifier activating enzyme 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117553, updated on 14-Nov-2024

Summary

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Official Symbol
Uba3provided by RGD
Official Full Name
ubiquitin-like modifier activating enzyme 3provided by RGD
Primary source
RGD:621084
See related
EnsemblRapid:ENSRNOG00000006221 AllianceGenome:RGD:621084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ube1c
Summary
Enables NEDD8 activating enzyme activity and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 288.5), Adrenal (RPKM 235.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uba3 in Genome Data Viewer
Location:
4q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (131346219..131367378, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (129789526..129810707, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (129548411..129569550, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene EGF domain specific O-linked N-acetylglucosamine transferase Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene TATA element modulatory factor 1 Neighboring gene uncharacterized LOC120102348 Neighboring gene ARF like GTPase 6 interacting protein 5 Neighboring gene leiomodin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice. Tateishi K, et al. J Cell Biol, 2001 Nov 12. PMID 11696557, Free PMC Article
  2. Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer. Bohnsack RN, et al. J Biol Chem, 2003 Jul 18. PMID 12740388
  3. The activating enzyme of NEDD8 inhibits steroid receptor function. Fan M, et al. Mol Endocrinol, 2002 Feb. PMID 11818503
  4. The mechanism of poly-NEDD8 chain formation in vitro. Ohki Y, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19245792
  5. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. Gong L, et al. J Biol Chem, 1999 Apr 23. PMID 10207026

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. activating enzyme of NEDD8 inhibits steroid receptor function
    Title: The activating enzyme of NEDD8 inhibits steroid receptor function.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NEDD8 activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables NEDD8 activating enzyme activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to NEDD8 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables NEDD8 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endomitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within endomitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein neddylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein neddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein neddylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NEDD8-activating enzyme E1 catalytic subunit
Names
NEDD8-activating enzyme E1C
ubiquitin-activating enzyme 3
ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)
NP_476553.1
XP_006236998.1
XP_063141501.1
XP_063141502.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057205.2 → NP_476553.1  NEDD8-activating enzyme E1 catalytic subunit

    See identical proteins and their annotated locations for NP_476553.1

    Status: VALIDATED

    Source sequence(s)
    BC081743
    UniProtKB/Swiss-Prot
    Q99MI7
    UniProtKB/TrEMBL
    A0A8L2Q4P8, A6IBF6
    Related
    ENSRNOP00000008893.9, ENSRNOT00000008893.9
    Conserved Domains (2) summary
    cd01488
    Location:71 → 368
    Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam08825
    Location:376 → 461
    E2_bind; E2 binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    131346219..131367378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236936.5 → XP_006236998.1  NEDD8-activating enzyme E1 catalytic subunit isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q4P8
    Related
    ENSRNOP00000108517.1, ENSRNOT00000133425.1
    Conserved Domains (2) summary
    cd01488
    Location:57 → 354
    Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    pfam08825
    Location:362 → 447
    E2_bind; E2 binding domain

  2. XM_063285431.1 → XP_063141501.1  NEDD8-activating enzyme E1 catalytic subunit isoform X2

    Related
    ENSRNOP00000086883.1, ENSRNOT00000117124.2

  3. XM_063285432.1 → XP_063141502.1  NEDD8-activating enzyme E1 catalytic subunit isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MI7.1 GenPept UniProtKB/Swiss-Prot:Q99MI7

Gene LinkOut

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