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Asb7 ankyrin repeat and SOCS box-containing 7 [ Mus musculus (house mouse) ]

Gene ID: 117589, updated on 2-Nov-2024

Summary

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Official Symbol
Asb7provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 7provided by MGI
Primary source
MGI:MGI:2152835
See related
Ensembl:ENSMUSG00000030509 AllianceGenome:MGI:2152835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-7; D030055C23Rik
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB7 (ankyrin repeat and SOCS box containing 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.5), whole brain E14.5 (RPKM 1.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Asb7 in Genome Data Viewer
Location:
7 C; 7 36.03 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (66294220..66339601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (66644565..66689879, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19085 Neighboring gene STARR-seq mESC enhancer starr_19088 Neighboring gene predicted gene, 53392 Neighboring gene predicted gene, 33570 Neighboring gene STARR-seq mESC enhancer starr_19090 Neighboring gene STARR-positive B cell enhancer ABC_E11356 Neighboring gene STARR-positive B cell enhancer ABC_E1735 Neighboring gene lines homolog 1 Neighboring gene STARR-seq mESC enhancer starr_19091 Neighboring gene ceramide synthase 3 Neighboring gene predicted gene, 33627 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ASB7 Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. Liu Y, et al. Front Cell Dev Biol, 2020. PMID 33251222, Free PMC Article
  2. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 7
Names
ankyrin repeat and SOCS box-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080443.2 → NP_536691.2  ankyrin repeat and SOCS box protein 7

    See identical proteins and their annotated locations for NP_536691.2

    Status: VALIDATED

    Source sequence(s)
    AC115761, AC120791
    Consensus CDS
    CCDS21346.1
    UniProtKB/Swiss-Prot
    G3UVX4, Q91ZU0
    Related
    ENSMUSP00000122395.2, ENSMUST00000124899.8
    Conserved Domains (4) summary
    PTZ00322
    Location:219 → 272
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:21 → 241
    PHA02875; ankyrin repeat protein; Provisional
    cd03726
    Location:273 → 317
    SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:81 → 114
    ANK; ANK repeat [structural motif]

RNA

  1. NR_003961.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115761, AC120791
    Related
    ENSMUST00000131320.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    66294220..66339601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540568.5 → XP_006540631.1  ankyrin repeat and SOCS box protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006540631.1

    UniProtKB/TrEMBL
    C0H5Y0
    Conserved Domains (4) summary
    PHA02876
    Location:4 → 200
    PHA02876; ankyrin repeat protein; Provisional
    cd03726
    Location:214 → 258
    SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:22 → 55
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:26 → 121
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006540567.5 → XP_006540630.1  ankyrin repeat and SOCS box protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006540630.1

    UniProtKB/Swiss-Prot
    G3UVX4, Q91ZU0
    Conserved Domains (4) summary
    PTZ00322
    Location:219 → 272
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    PHA02875
    Location:21 → 241
    PHA02875; ankyrin repeat protein; Provisional
    cd03726
    Location:273 → 317
    SOCS_ASB7; SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:81 → 114
    ANK; ANK repeat [structural motif]

RNA

  1. XR_004933996.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178236.3: Suppressed sequence

    Description
    NM_178236.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZU0.2 GenPept UniProtKB/Swiss-Prot:Q91ZU0

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