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Slc2a9 solute carrier family 2 (facilitated glucose transporter), member 9 [ Mus musculus (house mouse) ]

Gene ID: 117591, updated on 12-Nov-2024

Summary

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Official Symbol
Slc2a9provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 9provided by MGI
Primary source
MGI:MGI:2152844
See related
Ensembl:ENSMUSG00000005107 AllianceGenome:MGI:2152844
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut9; GLUT-9; SLC2A9B; SLC2a9A
Summary
Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 6.8), large intestine adult (RPKM 5.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Slc2a9 in Genome Data Viewer
Location:
5 B3; 5 20.43 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38506616..38660488, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38349272..38503147, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26560 Neighboring gene RIKEN cDNA 4930487D11 gene Neighboring gene dopamine receptor D5 Neighboring gene predicted gene, 40290 Neighboring gene STARR-seq mESC enhancer starr_12915 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:38871363-38871544 Neighboring gene VISTA enhancer mm253 Neighboring gene predicted gene 15796 Neighboring gene predicted gene, 54329

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse glucose transporter 9 splice variants are expressed in adult liver and kidney and are up-regulated in diabetes. Keembiyehetty C, et al. Mol Endocrinol, 2006 Mar. PMID 16293642
  2. SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney. Auberson M, et al. Pflugers Arch, 2018 Dec. PMID 30105595, Free PMC Article
  3. Mouse GLUT9: evidences for a urate uniporter. Bibert S, et al. Am J Physiol Renal Physiol, 2009 Sep. PMID 19587147
  4. METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells. Yang J, et al. Int Immunopharmacol, 2024 Dec 25. PMID 39393275
  5. SLC2A9 is a high-capacity urate transporter in humans. Caulfield MJ, et al. PLoS Med, 2008 Oct 7. PMID 18842065, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
    Title: METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
  2. The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
    Title: The regulation effect of GLUT9/SLC2A9 on intrahepatic uric acid level and metabolic associated fatty liver disease.
  3. Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
    Title: Glucose Transporter 9 (GLUT9) Plays an Important Role in the Placental Uric Acid Transport System.
  4. MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells in hyperuricemia.
    Title: MiR-143-3p directly targets GLUT9 to reduce uric acid reabsorption and inflammatory response of renal tubular epithelial cells.
  5. these data show that GLUT6 is dispensable for lipopolysaccharide-induced M1 polarization and function
    Title: Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function.
  6. SLC2A9 regulates urate reabsorption in the mouse kidney.
    Title: SLC2A9 (GLUT9) mediates urate reabsorption in the mouse kidney.
  7. Its anti-hyperuricemic mechanisms may be ascribed to its inhibition of XOD and its up-regulation of organic anion transporter 1 (OAT1) and down-regulation of glucose transporter 9 (GLUT9).
    Title: Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD.
  8. intestinal uric acid transporter SLC2A9 has a role in early-onset metabolic syndrome in a mouse model
    Title: Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9.
  9. Studies confirm the expression of GLUT9a and GLUT9b in murine and human beta-cells.
    Title: Facilitative glucose transporter 9 expression affects glucose sensing in pancreatic beta-cells.
  10. Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
    Title: Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables fructose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables hexose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables urate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables urate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in fructose transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in fructose transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monosaccharide transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in urate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in urate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in urate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in urate transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 9
Names
facilitated glucose transporter, type 9
glucose transporter type 9
urate transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012363.2 → NP_001012363.2  solute carrier family 2, facilitated glucose transporter member 9 isoform 2

    See identical proteins and their annotated locations for NP_001012363.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' CDS, compared to variant 1. The encoded protein (isoform 2, also known as the long form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC171271, AK033725, AY776155
    Consensus CDS
    CCDS51484.1
    UniProtKB/TrEMBL
    B9EHN5, Q5ERC7, Q8BZR3
    Related
    ENSMUSP00000066872.6, ENSMUST00000067872.12
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  2. NM_001102414.1 → NP_001095884.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 1

    See identical proteins and their annotated locations for NP_001095884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1, also known as the long form of mGLUT9a).
    Source sequence(s)
    AC171271, AK156740
    Consensus CDS
    CCDS51483.1
    UniProtKB/Swiss-Prot
    A0A0J9YUW8, B7ZNE4, B9EHN5, D3Z1X2, D6REU9, Q3T9X0, Q5ERC7, Q7TSK9, Q7TSP0, Q8BZR3, Q99JJ2
    Related
    ENSMUSP00000063352.6, ENSMUST00000067886.12
    Conserved Domains (1) summary
    cd17432
    Location:40 → 491
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  3. NM_001102415.1 → NP_001095885.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 3

    See identical proteins and their annotated locations for NP_001095885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 3, also known as the short form of mGLUT9a) lacks an internal region and is shorter, compared to isoform 1.
    Source sequence(s)
    AC084071, AC171271, AF490463
    Consensus CDS
    CCDS51482.1
    UniProtKB/TrEMBL
    Q7TSK9
    Related
    ENSMUSP00000118430.2, ENSMUST00000143758.8
    Conserved Domains (2) summary
    cd06174
    Location:42 → 372
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:40 → 388
    Sugar_tr; Sugar (and other) transporter

  4. NM_145559.2 → NP_663534.1  solute carrier family 2, facilitated glucose transporter member 9 isoform 4

    See identical proteins and their annotated locations for NP_663534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and CDS, and lacks two alternate in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform 4, also known as the short form of mGLUT9b) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC084071, BC006076
    Consensus CDS
    CCDS19256.1
    UniProtKB/TrEMBL
    Q99JJ2
    Related
    ENSMUSP00000005238.7, ENSMUST00000005238.13
    Conserved Domains (1) summary
    cl28910
    Location:25 → 369
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    38506616..38660488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503687.5 → XP_006503750.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

    See identical proteins and their annotated locations for XP_006503750.1

    UniProtKB/TrEMBL
    Q99JJ2
    Conserved Domains (1) summary
    cl28910
    Location:25 → 369
    MFS; Major Facilitator Superfamily

  2. XM_006503685.5 → XP_006503748.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    See identical proteins and their annotated locations for XP_006503748.1

    UniProtKB/TrEMBL
    B9EHN5
    Related
    ENSMUSP00000116354.2, ENSMUST00000155634.8
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  3. XM_006503684.5 → XP_006503747.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    See identical proteins and their annotated locations for XP_006503747.1

    UniProtKB/TrEMBL
    B9EHN5
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  4. XM_011240690.3 → XP_011238992.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    See identical proteins and their annotated locations for XP_011238992.1

    UniProtKB/TrEMBL
    B9EHN5
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  5. XM_011240689.4 → XP_011238991.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    See identical proteins and their annotated locations for XP_011238991.1

    UniProtKB/TrEMBL
    B9EHN5
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  6. XM_006503686.5 → XP_006503749.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X2

    See identical proteins and their annotated locations for XP_006503749.1

    UniProtKB/TrEMBL
    Q99JJ2
    Conserved Domains (1) summary
    cl28910
    Location:25 → 369
    MFS; Major Facilitator Superfamily

  7. XM_006503683.5 → XP_006503746.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    See identical proteins and their annotated locations for XP_006503746.1

    UniProtKB/TrEMBL
    B9EHN5
    Related
    ENSMUSP00000122723.2, ENSMUST00000129099.8
    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

  8. XM_030254075.2 → XP_030109935.1  solute carrier family 2, facilitated glucose transporter member 9 isoform X1

    Conserved Domains (1) summary
    cd17432
    Location:25 → 476
    MFS_GLUT_Class2; Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily

RNA

  1. XR_004942429.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3T9X0.1 GenPept UniProtKB/Swiss-Prot:Q3T9X0

Gene LinkOut

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