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Ap1s1 adaptor protein complex AP-1, sigma 1 [ Mus musculus (house mouse) ]

Gene ID: 11769, updated on 2-Nov-2024

Summary

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Official Symbol
Ap1s1provided by MGI
Official Full Name
adaptor protein complex AP-1, sigma 1provided by MGI
Primary source
MGI:MGI:1098244
See related
Ensembl:ENSMUSG00000004849 AllianceGenome:MGI:1098244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AP19
Summary
Predicted to enable clathrin adaptor activity. Acts upstream of or within retrograde transport, endosome to Golgi. Located in terminal bouton. Is active in presynapse. Human ortholog(s) of this gene implicated in MEDNIK syndrome. Orthologous to human AP1S1 (adaptor related protein complex 1 subunit sigma 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 34.6), frontal lobe adult (RPKM 34.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ap1s1 in Genome Data Viewer
Location:
5 G2; 5 76.13 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137063852..137074917, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137034993..137046108, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26989 Neighboring gene STARR-seq mESC enhancer starr_14633 Neighboring gene STARR-positive B cell enhancer ABC_E10359 Neighboring gene VGF nerve growth factor inducible Neighboring gene STARR-positive B cell enhancer ABC_E4796 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 1 Neighboring gene STARR-seq mESC enhancer starr_14636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:137579031-137579214 Neighboring gene tripartite motif-containing 56

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor AP-1, and the role of Fra-2. Foletta VC. Immunol Cell Biol, 1996 Apr. PMID 8723999
  2. Momordin I, an inhibitor of AP-1, suppressed osteoclastogenesis through inhibition of NF-kappaB and AP-1 and also reduced osteoclast activity and survival. Hwang YH, et al. Biochem Biophys Res Commun, 2005 Nov 25. PMID 16213465
  3. Serum response factor mediates AP-1-dependent induction of the skeletal alpha-actin promoter in ventricular myocytes. Paradis P, et al. J Biol Chem, 1996 May 3. PMID 8631897
  4. Differential inhibition of UVB-induced AP-1 and NF-kappaB transactivation by components of the jun bZIP domain. Cooper S, et al. Mol Carcinog, 2005 Jun. PMID 15791649
  5. Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects. Moreno E, et al. J Neurosci, 2014 Mar 5. PMID 24599455, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in basolateral protein secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in intracellular protein transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in melanosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet dense granule organization NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network NAS
Non-traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
AP-1 complex subunit sigma-1A
Names
HA1 19 kDa subunit
adapter-related protein complex 1 sigma-1A subunit
adapter-related protein complex 1 subunit sigma-1A
adaptor protein complex AP-1 sigma-1A subunit
adaptor protein complex AP-1 subunit sigma-1A
adaptor-related protein complex 1 subunit sigma-1A
adaptor-related protein complex AP-1, sigma 1
clathrin assembly protein complex 1 sigma-1A small chain
clathrin coat assembly protein AP19
golgi adaptor HA1/AP1 adaptin sigma-1A subunit
sigma 1a subunit of AP-1 clathrin
sigma-adaptin 1A
sigma1A-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420721.1 → NP_001407650.1  AP-1 complex subunit sigma-1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC147986

  2. NM_001420722.1 → NP_001407651.1  AP-1 complex subunit sigma-1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC147986

  3. NM_007457.4 → NP_031483.1  AP-1 complex subunit sigma-1A isoform 1

    See identical proteins and their annotated locations for NP_031483.1

    Status: VALIDATED

    Source sequence(s)
    AC147986
    Consensus CDS
    CCDS39330.1
    UniProtKB/Swiss-Prot
    P61967
    UniProtKB/TrEMBL
    D3Z0D6
    Related
    ENSMUSP00000106709.2, ENSMUST00000111080.8
    Conserved Domains (1) summary
    cd14831
    Location:3 → 145
    AP1_sigma; AP-1 complex subunit sigma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137063852..137074917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61967.1 GenPept UniProtKB/Swiss-Prot:P61967

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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