U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ap2a1 adaptor-related protein complex 2, alpha 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 11771, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ap2a1provided by MGI
Official Full Name
adaptor-related protein complex 2, alpha 1 subunitprovided by MGI
Primary source
MGI:MGI:101921
See related
Ensembl:ENSMUSG00000060279 AllianceGenome:MGI:101921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adtaa
Summary
Enables protein kinase binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in filopodium tip. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and postsynaptic endocytic zone. Is expressed in brain; cranial ganglion; dorsal root ganglion; and liver. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 120.3), ovary adult (RPKM 49.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ap2a1 in Genome Data Viewer
Location:
7 B3; 7 29.01 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44549797..44578914, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44900373..44929490, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene polynucleotide kinase 3'- phosphatase Neighboring gene prostate tumor over expressed gene 1 Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene testis-specific serine kinase substrate Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression and localization of alpha-adaptin isoforms. Ball CL, et al. J Cell Sci, 1995 Aug. PMID 7593326
  2. Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses. López-Hernández T, et al. Elife, 2022 Jan 11. PMID 35014951, Free PMC Article
  3. BRAG2a Mediates mGluR-Dependent AMPA Receptor Internalization at Excitatory Postsynapses through the Interaction with PSD-95 and Endophilin 3. Fukaya M, et al. J Neurosci, 2020 May 27. PMID 32341099, Free PMC Article
  4. Disruption of the murine Ap2β1 gene causes nonsyndromic cleft palate. Li W, et al. Cleft Palate Craniofac J, 2010 Nov. PMID 20500056, Free PMC Article
  5. Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). Robinson MS. J Cell Biol, 1989 Mar. PMID 2564002, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SP-A transiently enhances the basal protein expression of CHC and alpha-adaptin.
    Title: Surfactant Protein A Enhances Constitutive Immune Functions of Clathrin Heavy Chain and Clathrin Adaptor Protein 2.
  2. AP2 protein expression was regulated in a vitamin A-deficiennt mouse developing eye.
    Title: Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hyaluronan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynaptic neurotransmitter receptor internalization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-2 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in filopodium tip IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of membrane coat IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endocytic zone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in secretory granule TAS
Traceable Author Statement
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
AP-2 complex subunit alpha-1
Names
100 kDa coated vesicle protein A
adapter-related protein complex 2 alpha-1 subunit
adapter-related protein complex 2 subunit alpha-1
adaptor protein complex AP-2 subunit alpha-1
adaptor protein complex AP-2, alpha 1 subunit
adaptor-related protein complex 2 subunit alpha-1
adaptor-related protein complex AP-2, alpha 1 subunit
alpha-adaptin A
alpha1-adaptin
clathrin assembly protein complex 2 alpha-A large chain
plasma membrane adaptor HA2/AP2 adaptin alpha A subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077264.1 → NP_001070732.1  AP-2 complex subunit alpha-1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform b) is shorter but has the same N- and C-termini compared to isoform a.
    Source sequence(s)
    AK135424, BC031433, CA327188
    Consensus CDS
    CCDS52238.1
    UniProtKB/Swiss-Prot
    P17426
    Related
    ENSMUSP00000103489.4, ENSMUST00000107857.11
    Conserved Domains (4) summary
    smart00809
    Location:733 → 836
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:842 → 950
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

  2. NM_007458.2 → NP_031484.1  AP-2 complex subunit alpha-1 isoform a

    See identical proteins and their annotated locations for NP_031484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
    Source sequence(s)
    BC031433, CA327188
    Consensus CDS
    CCDS52239.1
    UniProtKB/Swiss-Prot
    P17426
    Related
    ENSMUSP00000127842.2, ENSMUST00000166972.9
    Conserved Domains (4) summary
    smart00809
    Location:755 → 858
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:864 → 972
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44549797..44578914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540569.5 → XP_006540632.1  AP-2 complex subunit alpha-1 isoform X1

    Conserved Domains (3) summary
    smart00809
    Location:679 → 782
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1 → 515
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:788 → 896
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain

  2. XM_006540570.1 → XP_006540633.1  AP-2 complex subunit alpha-1 isoform X2

    Conserved Domains (3) summary
    smart00809
    Location:403 → 506
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:1 → 239
    Adaptin_N; Adaptin N terminal region
    pfam02296
    Location:512 → 620
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17426.1 GenPept UniProtKB/Swiss-Prot:P17426

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous