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Aqp5 aquaporin 5 [ Mus musculus (house mouse) ]

Gene ID: 11830, updated on 28-Oct-2024

Summary

Official Symbol
Aqp5provided by MGI
Official Full Name
aquaporin 5provided by MGI
Primary source
MGI:MGI:106215
See related
Ensembl:ENSMUSG00000044217 AllianceGenome:MGI:106215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity and water channel activity. Acts upstream of or within camera-type eye morphogenesis; saliva secretion; and water transport. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and microvillus. Is expressed in several structures, including exocrine system; lung; nucleus pulposus; oocyte; and sensory organ. Used to study dry eye syndrome. Human ortholog(s) of this gene implicated in Bothnian type palmoplantar keratoderma. Orthologous to human AQP5 (aquaporin 5). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in lung adult (RPKM 187.0), mammary gland adult (RPKM 72.8) and 4 other tissues See more
Orthologs
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Genomic context

See Aqp5 in Genome Data Viewer
Location:
15 F1; 15 56.13 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99488909..99492710)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99591028..99594829)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5808 Neighboring gene predicted gene, 34765 Neighboring gene STARR-seq mESC enhancer starr_39713 Neighboring gene aquaporin 2 Neighboring gene aquaporin 6 Neighboring gene Rac GTPase-activating protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99481947-99482248

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables water channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in carbon dioxide transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in carbon dioxide transport IEA
Inferred from Electronic Annotation
more info
 
involved_in carbon dioxide transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular hypotonic response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in odontogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within water transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in water transport ISO
Inferred from Sequence Orthology
more info
 
involved_in water transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within water transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009701.4NP_033831.1  aquaporin-5

    See identical proteins and their annotated locations for NP_033831.1

    Status: VALIDATED

    Source sequence(s)
    AC139317, AK009302
    Consensus CDS
    CCDS27823.1
    UniProtKB/Swiss-Prot
    Q545H1, Q9WTY4
    UniProtKB/TrEMBL
    B2RWZ5
    Related
    ENSMUSP00000127611.2, ENSMUST00000169082.3
    Conserved Domains (1) summary
    pfam00230
    Location:4221
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    99488909..99492710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)