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Rhoc ras homolog family member C [ Mus musculus (house mouse) ]

Gene ID: 11853, updated on 2-Nov-2024

Summary

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Official Symbol
Rhocprovided by MGI
Official Full Name
ras homolog family member Cprovided by MGI
Primary source
MGI:MGI:106028
See related
Ensembl:ENSMUSG00000002233 AllianceGenome:MGI:106028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arh9; Arhc
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in apical junction assembly and positive regulation of protein-containing complex assembly. Located in nucleus; plasma membrane; and stereocilium. Is expressed in hippocampus. Orthologous to human RHOC (ras homolog family member C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 107.6), colon adult (RPKM 105.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rhoc in Genome Data Viewer
Location:
3 F2.2; 3 45.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (104696350..104701775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (104789034..104794459)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 3 Neighboring gene STARR-seq mESC enhancer starr_08620 Neighboring gene protein phosphatase 1J Neighboring gene Mov10 RISC complex RNA helicase Neighboring gene STARR-seq mESC enhancer starr_08622 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation. Raghuram N, et al. Breast Cancer Res, 2024 May 28. PMID 38807216, Free PMC Article
  2. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Hakem A, et al. Genes Dev, 2005 Sep 1. PMID 16107613, Free PMC Article
  3. RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. Ruth MC, et al. J Invest Dermatol, 2006 Apr. PMID 16470169
  4. A definitive role of RhoC in metastasis of orthotopic lung cancer in mice. Ikoma T, et al. Clin Cancer Res, 2004 Feb 1. PMID 14871999
  5. RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis. Egami Y, et al. J Cell Sci, 2017 Dec 15. PMID 29113998

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation.
    Title: Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation.
  2. what was seen for RhoC, mDia1 silencing through RNAi inhibited phagosome formation. Additionally, the coexpression of mDia1 with constitutively active mutant RhoC-G14V or expression of active mutant mDia1-DeltaN3 drastically inhibited the uptake of IgG-Es. These data suggest that RhoC modulates phagosome formation be modifying actin cytoskeletal remodeling via mDia1
    Title: RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.
  3. RhoC co-localizes with Fam65b in stereocilia and regulates Fam65b oligomerization what is critical for hair cell function.
    Title: Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function.
  4. Inhibition of ovarian epithelial carcinoma tumorigenesis and progression by miR106b proceeds through the RhoC pathway.
    Title: Inhibition of Ovarian Epithelial Carcinoma Tumorigenesis and Progression by microRNA 106b Mediated through the RhoC Pathway.
  5. RHOC and RAB38 are dispensable for osteoclast function.
    Title: The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption.
  6. A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.
    Title: A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.
  7. We found that both RhoA and RhoC, but not RhoB, were required for initiation of centrosome duplication, and overactivation of RhoA, as well as RhoC, but not RhoB, promoted centrosome duplication and centrosome amplification.
    Title: RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.
  8. RhoC has a role in metastasis of lung cancer in mice
    Title: A definitive role of RhoC in metastasis of orthotopic lung cancer in mice.
  9. loss of RhoC does not affect tumor development but decreases tumor cell motility and metastatic cell survival leading to a drastic inhibition of metastasis
    Title: RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
  10. RhoC promotes melanoma progression via separate mechanisms that regulate the PI3K/Akt pathway and the ROCK signaling pathway.
    Title: RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apical junction assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in apical junction assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of lipase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in skeletal muscle satellite cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
  
located_in cleavage furrow ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in stereocilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rho-related GTP-binding protein RhoC
Names
SIG-61
aplysia ras-related homolog 9 (RhoC)
ras homolog 9 (RhoC)
ras homolog gene family, member C
silica-induced gene 61 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291859.1 → NP_001278788.1  rho-related GTP-binding protein RhoC

    See identical proteins and their annotated locations for NP_001278788.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BY315470, CO044736, CX223083
    Consensus CDS
    CCDS17704.1
    UniProtKB/Swiss-Prot
    Q3TUN0, Q62159
    UniProtKB/TrEMBL
    Q3TN61
    Related
    ENSMUSP00000102399.2, ENSMUST00000106787.8
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

  2. NM_007484.2 → NP_031510.2  rho-related GTP-binding protein RhoC

    See identical proteins and their annotated locations for NP_031510.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI324259, AK160650, BY147599
    Consensus CDS
    CCDS17704.1
    UniProtKB/Swiss-Prot
    Q3TUN0, Q62159
    UniProtKB/TrEMBL
    Q3TN61
    Related
    ENSMUSP00000002303.6, ENSMUST00000002303.12
    Conserved Domains (1) summary
    cd01870
    Location:5 → 179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    104696350..104701775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62159.2 GenPept UniProtKB/Swiss-Prot:Q62159

Gene LinkOut

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