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Rhod ras homolog family member D [ Mus musculus (house mouse) ]

Gene ID: 11854, updated on 2-Nov-2024

Summary

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Official Symbol
Rhodprovided by MGI
Official Full Name
ras homolog family member Dprovided by MGI
Primary source
MGI:MGI:108446
See related
Ensembl:ENSMUSG00000041845 AllianceGenome:MGI:108446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rho; Arhd; RhoM; RhoHP1
Summary
Enables GTP binding activity and protein kinase binding activity. Involved in regulation of actin cytoskeleton organization and regulation of focal adhesion assembly. Acts upstream of or within several processes, including actin filament polymerization; fibroblast growth factor receptor signaling pathway; and protein targeting. Is active in cell projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human RHOD (ras homolog family member D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in small intestine adult (RPKM 37.3), duodenum adult (RPKM 29.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Rhod in Genome Data Viewer
Location:
19 A; 19 4.07 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4473500..4489562, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4423472..4439534, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4294334-4294632 Neighboring gene STARR-positive B cell enhancer ABC_E7626 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302085-4302194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:4302330-4302483 Neighboring gene STARR-positive B cell enhancer ABC_E9988 Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene STARR-seq mESC enhancer starr_45347 Neighboring gene lysine (K)-specific demethylase 2A Neighboring gene RIKEN cDNA 9430078G10 gene Neighboring gene STARR-positive B cell enhancer ABC_E1521 Neighboring gene STARR-seq mESC enhancer starr_45348 Neighboring gene RIKEN cDNA A930001C03 gene Neighboring gene STARR-seq mESC enhancer starr_45349 Neighboring gene synaptotagmin XII Neighboring gene RIKEN cDNA 2010003K11 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endosome dynamics regulated by a Rho protein. Murphy C, et al. Nature, 1996 Dec 5. PMID 8945468
  2. Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking. Gad AK, et al. Cell Signal, 2010 Feb. PMID 19818399
  3. Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking. Aspenström P. Biol Chem, 2014 May. PMID 24622787
  4. Small GTPase RhoD suppresses cell migration and cytokinesis. Tsubakimoto K, et al. Oncogene, 1999 Apr 15. PMID 10229194
  5. The RhoD to centrosomal duplication. Kyrkou A, et al. Small GTPases, 2013 Apr-Jun. PMID 23422264, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RhoD was activated by FGF signaling, and RhoD-activated mDia3C was responsible for the actin filament formation in the protrusion.
    Title: RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
  2. Lysophosphatidic acid signals through LPA2 receptors and Galphaq proteins of cultured proximal tubule cells to transactivate latent TGF-beta in a Rho/Rho-kinase and alphavbeta6 integrin-dependent manner.
    Title: Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β.
  3. Podocyte BK(Ca) channels are regulated by synaptopodin, Rho, and actin microfilaments.
    Title: Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.
  4. ERK5 promotes Src-induced podosome formation by inducing RhoGAP7 and thereby limiting Rho activation.
    Title: ERK5 promotes Src-induced podosome formation by limiting Rho activation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within actin filament polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell projection assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein targeting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to fibroblast growth factor IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to fibroblast growth factor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoD
Names
aplysia ras-related homolog D
ras homolog D (RhoD)
ras homolog gene family, member D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329989.1 → NP_001316918.1  rho-related GTP-binding protein RhoD isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124347, AK008880, BX516716
    UniProtKB/TrEMBL
    Q545H8

  2. NM_007485.5 → NP_031511.1  rho-related GTP-binding protein RhoD isoform 1

    See identical proteins and their annotated locations for NP_031511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC124347, AK008880, BX516716
    Consensus CDS
    CCDS29427.1
    UniProtKB/Swiss-Prot
    O09104, P97348
    UniProtKB/TrEMBL
    Q545H8
    Related
    ENSMUSP00000036031.4, ENSMUST00000048197.10
    Conserved Domains (2) summary
    smart00174
    Location:20 → 192
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd04132
    Location:17 → 208
    Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4473500..4489562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531644.3 → XP_006531707.1  rho-related GTP-binding protein RhoD isoform X1

    See identical proteins and their annotated locations for XP_006531707.1

    UniProtKB/TrEMBL
    G3X9Y4
    Related
    ENSMUSP00000112607.2, ENSMUST00000117462.2
    Conserved Domains (1) summary
    smart00174
    Location:20 → 160
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97348.1 GenPept UniProtKB/Swiss-Prot:P97348

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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