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Arhgap5 Rho GTPase activating protein 5 [ Mus musculus (house mouse) ]

Gene ID: 11855, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap5provided by MGI
Official Full Name
Rho GTPase activating protein 5provided by MGI
Primary source
MGI:MGI:1332637
See related
Ensembl:ENSMUSG00000035133 AllianceGenome:MGI:1332637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p190B; p190-B
Summary
Predicted to enable GTPase activator activity and SH2 domain binding activity. Acts upstream of or within several processes, including positive regulation of epithelial cell migration; positive regulation of mesenchymal cell proliferation; and regulation of cell size. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ARHGAP5 (Rho GTPase activating protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 9.8), frontal lobe adult (RPKM 6.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap5 in Genome Data Viewer
Location:
12 C1; 12 22.16 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (52550555..52618761)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (52503763..52571978)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35071 Neighboring gene predicted gene, 35135 Neighboring gene RIKEN cDNA 1700031P21 gene Neighboring gene STARR-seq mESC enhancer starr_32132 Neighboring gene STARR-positive B cell enhancer ABC_E4025 Neighboring gene predicted gene, 35239 Neighboring gene predicted gene, 24859

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p190-B RhoGAP regulates mammary ductal morphogenesis. Chakravarty G, et al. Mol Endocrinol, 2003 Jun. PMID 12637587
  2. Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Sordella R, et al. Cell, 2003 Apr 18. PMID 12705864
  3. p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation. Hinge A, et al. Nat Commun, 2017 Feb 8. PMID 28176763, Free PMC Article
  4. p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment. Raman R, et al. Leukemia, 2013 Nov. PMID 23563238, Free PMC Article
  5. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential. Xu H, et al. Blood, 2009 Oct 22. PMID 19713466, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study suggests a link between p190-B-RhoGAP and non-canonical TGF-beta signaling in hematopoietic stem and progenitor cell differentiation.
    Title: p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
  2. Loss of p190-B expression is associated with defective hematopoiesis.
    Title: p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
  3. Rac1 activity and oxidative stress are elevated in tumors expressing exogenous p190B suggesting that p190B may promote tumorigenesis through a Rac1/ROS dependent mechanism.
    Title: P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.
  4. p190B haploinsufficiency in the epithelium inhibits MMTV-Neu tumor initiation. p190B deficiency in the vasculature is responsible, in part, for the inhibition of MMTV-Neu tumor progression.
    Title: Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
  5. Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
    Title: Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
  6. IGF signaling through p190-B and IRS proteins is critical for mammary bud formation and ensuing epithelial-mesenchymal interactions necessary to sustain mammary bud morphogenesis
    Title: Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
  7. Mice lacking the Rho-inhibitory protein, p190-B RhoGAP, are 30% reduced in size and exhibit developmental defects strikingly similar to those seen in mice lacking the CREB transcription factor.
    Title: Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development.
  8. Results suggest that p190-B regulates ductal morphogenesis, at least in part, by modulating the IGF signaling axis
    Title: p190-B RhoGAP regulates mammary ductal morphogenesis.
  9. precise control of p190-B Rho GTPase-activating protein activity is critical for normal branching morphogenesis during mammary gland development
    Title: P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 5
Names
rho-type GTPase-activating protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408721.1 → NP_001395650.1  rho GTPase-activating protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819
    UniProtKB/Swiss-Prot
    E9PYT0, E9Q0L8, P97393
    Related
    ENSMUSP00000106353.2, ENSMUST00000110725.2

  2. NM_001408722.1 → NP_001395651.1  rho GTPase-activating protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819
    UniProtKB/Swiss-Prot
    E9PYT0, E9Q0L8, P97393
    Related
    ENSMUSP00000151809.2, ENSMUST00000219443.2

  3. NM_001408723.1 → NP_001395652.1  rho GTPase-activating protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819

  4. NM_001408724.1 → NP_001395653.1  rho GTPase-activating protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819

  5. NM_009706.3 → NP_033836.2  rho GTPase-activating protein 5 isoform 1

    See identical proteins and their annotated locations for NP_033836.2

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819
    Consensus CDS
    CCDS36443.1
    UniProtKB/Swiss-Prot
    E9PYT0, E9Q0L8, P97393
    Conserved Domains (4) summary
    smart00441
    Location:428 → 481
    FF; Contains two conserved F residues
    cd04373
    Location:1261 → 1445
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:260 → 338
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl38936
    Location:31 → 246
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_176796.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819

  2. NR_176797.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114002, AC155819

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    52550555..52618761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97393.3 GenPept UniProtKB/Swiss-Prot:P97393

Gene LinkOut

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