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Art2b ADP-ribosyltransferase 2b [ Mus musculus (house mouse) ]

Gene ID: 11872, updated on 2-Nov-2024

Summary

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Official Symbol
Art2bprovided by MGI
Official Full Name
ADP-ribosyltransferase 2bprovided by MGI
Primary source
MGI:MGI:107545
See related
Ensembl:ENSMUSG00000030651 AllianceGenome:MGI:107545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Art; Rt6; Rt-6; ARTC2; Ly92b; Rt6-2; ART2.2
Summary
Enables NAD+-protein-arginine ADP-ribosyltransferase activity and hydrolase activity, acting on glycosyl bonds. Involved in NAD catabolic process. Located in external side of plasma membrane. Orthologous to human ART2BP (ADP-ribosyltransferase 2B, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 3.9), mammary gland adult (RPKM 1.9) and 6 other tissues See more
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Genomic context

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See Art2b in Genome Data Viewer
Location:
7 E2; 7 54.61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101224936..101234790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101575729..101585591, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19765 Neighboring gene ADP-ribosyltransferase 2a Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 45995 Neighboring gene STARR-seq mESC enhancer starr_19695 Neighboring gene STARR-positive B cell enhancer ABC_E10456 Neighboring gene STARR-positive B cell enhancer ABC_E4958 Neighboring gene STARR-seq mESC enhancer starr_19696 Neighboring gene ClpB caseinolytic peptidase B Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2. Menzel S, et al. J Immunol, 2015 Sep 1. PMID 26209623
  2. Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death. Bannas P, et al. Mol Immunol, 2011 Sep. PMID 21641039
  3. Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts. Bannas P, et al. Blood, 2005 May 1. PMID 15657180
  4. A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo. Gondé H, et al. Front Immunol, 2021. PMID 34489954, Free PMC Article
  5. Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies. Georgiev H, et al. Eur J Immunol, 2018 Jun. PMID 29508376

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
    Title: A Methodological Approach Using rAAV Vectors Encoding Nanobody-Based Biologics to Evaluate ARTC2.2 and P2X7 In Vivo.
  2. Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
    Title: Identification of the Mouse T Cell ADP-Ribosylome Uncovers ARTC2.2 Mediated Regulation of CD73 by ADP-Ribosylation.
  3. this study shows that blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies
    Title: Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies.
  4. Data show that shedding of T Cell Ecto-ADP-ribosyltransferase ARTC2.2 alters its substrate profile.
    Title: Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.
  5. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
    Title: Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
  6. Extracellular nicotinamide adenine dinucleotide (NAD)/ART2-dependent modification of the P2X7R purinergic receptor potentiates the ability of adenosine triphosphate (ATP) to activate the receptor, via a left shift in the ATP dose-response relationship.
    Title: Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.
  7. Transfer of a genetically disrupted CD38 allele into the autoimmune diabetes-prone NOD/Lt background accelerated diabetes onset in both sexes, whereas transfer of a disrupted ART2a/b complex had no effect.
    Title: Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
  8. ART2b is required for ADP-ribosylation of cell surface proteins
    Title: Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.
  9. CD38 controls the level of cell surface protein ADP-ribosylation by limiting the substrate availability for ART2.
    Title: CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.
  10. raft association focuses ART2.2 on specific targets that constitutively or inducibly associate with lipid rafts
    Title: Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
  
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydrolase activity, acting on glycosyl bonds IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
T-cell ecto-ADP-ribosyltransferase 2
Names
ADP-ribosyltransferase C2 and C3 toxin-like 2
NAD(+) glycohydrolase
T-cell NAD(P)(+)--arginine ADP-ribosyltransferase 2
T-cell differentiation marker Rt6 homolog 2
T-cell mono(ADP-ribosyl)transferase 2
mono(ADP-ribosyl)transferase 2B
NP_064299.2
XP_006507319.1
XP_017177440.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019915.3 → NP_064299.2  T-cell ecto-ADP-ribosyltransferase 2 precursor

    See identical proteins and their annotated locations for NP_064299.2

    Status: VALIDATED

    Source sequence(s)
    AC129609, AF016465
    Consensus CDS
    CCDS21512.1
    UniProtKB/Swiss-Prot
    F8VQK8, O35702, O35975
    UniProtKB/TrEMBL
    A0A1B0GQV6
    Related
    ENSMUSP00000065658.3, ENSMUST00000063920.3
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 242
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101224936..101234790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507256.4 → XP_006507319.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006507319.1

    UniProtKB/Swiss-Prot
    F8VQK8, O35702, O35975
    UniProtKB/TrEMBL
    A0A1B0GQV6
    Related
    ENSMUSP00000147267.2, ENSMUST00000209526.2
    Conserved Domains (1) summary
    pfam01129
    Location:27 → 242
    ART; NAD:arginine ADP-ribosyltransferase

  2. XM_017321951.2 → XP_017177440.1  T-cell ecto-ADP-ribosyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GQV6
    Conserved Domains (1) summary
    pfam01129
    Location:38 → 253
    ART; NAD:arginine ADP-ribosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35975.2 GenPept UniProtKB/Swiss-Prot:O35975

Gene LinkOut

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