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Atp5pb ATP synthase peripheral stalk-membrane subunit b [ Mus musculus (house mouse) ]

Gene ID: 11950, updated on 3-Nov-2024

Summary

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Official Symbol
Atp5pbprovided by MGI
Official Full Name
ATP synthase peripheral stalk-membrane subunit bprovided by MGI
Primary source
MGI:MGI:1100495
See related
Ensembl:ENSMUSG00000000563 AllianceGenome:MGI:1100495
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5f1
Summary
Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in proton motive force-driven mitochondrial ATP synthesis. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ATP5PB (ATP synthase peripheral stalk-membrane subunit b). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 196.9), heart adult (RPKM 162.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Atp5pb in Genome Data Viewer
Location:
3 F2.2; 3 46.46 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105850014..105866579, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105942698..105959263, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene adenosine A3 receptor Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene WD repeat domain 77 Neighboring gene oviductal glycoprotein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. Lehman JJ, et al. J Clin Invest, 2000 Oct. PMID 11018072, Free PMC Article
  2. A Mutation in Hnrnph1 That Decreases Methamphetamine-Induced Reinforcement, Reward, and Dopamine Release and Increases Synaptosomal hnRNP H and Mitochondrial Proteins. Ruan QT, et al. J Neurosci, 2020 Jan 2. PMID 31704785, Free PMC Article
  3. Modulation of gene expression in the preimplantation mouse embryo by TGF-alpha and TGF-beta. Babalola GO, et al. Mol Reprod Dev, 1995 Jun. PMID 7654366
  4. TRIB3 promotes pulmonary fibrosis through inhibiting SLUG degradation by physically interacting with MDM2. Lv X, et al. Acta Pharm Sin B, 2023 Apr. PMID 37139431, Free PMC Article
  5. Phosphoinositide-specific phospholipase C β 1b (PI-PLCβ1b) interactome: affinity purification-mass spectrometry analysis of PI-PLCβ1b with nuclear protein. Piazzi M, et al. Mol Cell Proteomics, 2013 Aug. PMID 23665500, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATP synthase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath HDA PubMed 
part_of proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP synthase F(0) complex subunit B1, mitochondrial
Names
ATP synthase subunit b, mitochondrial
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1
ATPase subunit b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304719.2 → NP_001291648.1  ATP synthase F(0) complex subunit B1, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' region and uses an alternate start codon compared to variant 1. It encodes isoform 2 which has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC025786
    UniProtKB/TrEMBL
    Q3TJD4, Q3UF04
    Conserved Domains (1) summary
    pfam05405
    Location:58 → 219
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

  2. NM_009725.5 → NP_033855.2  ATP synthase F(0) complex subunit B1, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_033855.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC025786
    Consensus CDS
    CCDS17714.1
    UniProtKB/Swiss-Prot
    Q9CQQ7
    UniProtKB/TrEMBL
    Q3TJD4, Q3UF04, Q5I0W0
    Related
    ENSMUSP00000113022.2, ENSMUST00000118209.8
    Conserved Domains (1) summary
    pfam05405
    Location:83 → 244
    Mt_ATP-synt_B; Mitochondrial ATP synthase B chain precursor (ATP-synt_B)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105850014..105866579 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQQ7.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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