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OR52M1 olfactory receptor family 52 subfamily M member 1 [ Homo sapiens (human) ]

Gene ID: 119772, updated on 5-Mar-2024

Summary

Official Symbol
OR52M1provided by HGNC
Official Full Name
olfactory receptor family 52 subfamily M member 1provided by HGNC
Primary source
HGNC:HGNC:15225
See related
Ensembl:ENSG00000197790 AllianceGenome:HGNC:15225
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-11; OR52M1P; OR52M3P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4545191..4546144)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4610461..4611414)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4566421..4567374)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily K member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4324 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:4516376-4517575 Neighboring gene olfactory receptor family 52 subfamily M member 2 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:4544619-4545119 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:4590598-4590803 Neighboring gene chromosome 11 putative open reading frame 40 Neighboring gene olfactory receptor family 52 subfamily I member 2

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 52M1
Names
olfactory receptor OR11-11
olfactory receptor, family 52, subfamily M, member 1 pseudogene
olfactory receptor, family 52, subfamily M, member 3 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004137.1NP_001004137.1  olfactory receptor 52M1

    See identical proteins and their annotated locations for NP_001004137.1

    Status: VALIDATED

    Source sequence(s)
    AC090719
    Consensus CDS
    CCDS31353.1
    UniProtKB/Swiss-Prot
    Q8NGK5
    UniProtKB/TrEMBL
    A0A126GVG8
    Related
    ENSP00000353343.1, ENST00000360213.1
    Conserved Domains (2) summary
    pfam00001
    Location:43295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33309
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    4545191..4546144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    4610461..4611414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)