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Atp10a ATPase, class V, type 10A [ Mus musculus (house mouse) ]

Gene ID: 11982, updated on 2-Nov-2024

Summary

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Official Symbol
Atp10aprovided by MGI
Official Full Name
ATPase, class V, type 10Aprovided by MGI
Primary source
MGI:MGI:1330809
See related
Ensembl:ENSMUSG00000025324 AllianceGenome:MGI:1330809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pfatp; Atp10c
Summary
Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of membrane tubulation. Predicted to be located in endoplasmic reticulum. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; dorsal grey horn; lung; and testis. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 15.3), adrenal adult (RPKM 11.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Atp10a in Genome Data Viewer
Location:
7 B5; 7 33.88 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (58305896..58479783)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (58656142..58830244)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26288 Neighboring gene STARR-seq mESC enhancer starr_18982 Neighboring gene STARR-positive B cell enhancer ABC_E6550 Neighboring gene nuclear encoded tRNA glutamic acid 7 (anticodon TTC) Neighboring gene STARR-seq mESC enhancer starr_18985 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65913391-65913574 Neighboring gene STARR-seq mESC enhancer starr_18986 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65952583-65952778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:65997400-65997583 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:66010520-66010731 Neighboring gene predicted gene, 39019 Neighboring gene non-catalytic region of tyrosine kinase adaptor protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18988 Neighboring gene STARR-seq mESC enhancer starr_18989 Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice. Norris AC, et al. Sci Rep, 2024 Jan 3. PMID 38172157, Free PMC Article
  2. Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb. Kashiwagi A, et al. J Hum Genet, 2003. PMID 12730723
  3. Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting. Kayashima T, et al. Genomics, 2003 Jun. PMID 12782135
  4. Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes. Dhar MS, et al. J Nutr, 2004 Apr. PMID 15051828
  5. The human aminophospholipid-transporting ATPase gene ATP10C maps adjacent to UBE3A and exhibits similar imprinted expression. Herzing LB, et al. Am J Hum Genet, 2001 Jun. PMID 11353404, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
    Title: Deficiency of the lipid flippase ATP10A causes diet-induced dyslipidemia in female mice.
  2. Data report that Atp10a is biallelically expressed in both the newborn and adult brain, and Atp10a allelic expression is insensitive to deletion or mutation of the PWS imprinting center.
    Title: Atp10a, a gene adjacent to the PWS/AS gene cluster, is not imprinted in mouse and is insensitive to the PWS-IC.
  3. report the generation of the complete genomic structure
    Title: An aminophospholipid translocase associated with body fat and type 2 diabetes phenotypes.
  4. Atp10a was biallelically expressed in all tissues examined. Furthermore, there was no differential methylation in the CpG island and no antisense transcripts of the gene. These findings suggest that the mouse Atp10a gene escapes genomic imprinting.
    Title: Atp10a, the mouse ortholog of the human imprinted ATP10A gene, escapes genomic imprinting.
  5. A putative phospholipid transporter, is the only coding unit between Gabrb3 and Ube3a.
    Title: Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3a.
  6. Atp10c/pfatp showed tissue-specific maternal expression in the hippocampus and olfactory bulb
    Title: Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb.
  7. data suggest that heterozygous deletion along with an unusual pattern of maternal inheritance of the chromosomal region containing the single gene, Atp10c, causes obesity, type 2 diabetes, and nonalcoholic fatty liver disease in these mice
    Title: Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosylceramide flippase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosylceramide flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine flippase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylcholine flippase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylcholine floppase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane tubulation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of phospholipid-translocating ATPase complex IEA
Inferred from Electronic Annotation
more info
  
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phospholipid-transporting ATPase VA
Names
ATPase 10A, class V
ATPase, class 5
P-locus fat-associated ATPase
P4-ATPase flippase complex alpha subunit ATP10A
probable phospholipid-transporting ATPase VA
NP_033858.2
XP_006540643.1
XP_006540644.1
XP_006540646.1
XP_017177441.1
XP_036008505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009728.2 → NP_033858.2  phospholipid-transporting ATPase VA

    See identical proteins and their annotated locations for NP_033858.2

    Status: VALIDATED

    Source sequence(s)
    AC163271, AK132174, AK172972, AV273066
    Consensus CDS
    CCDS39972.1
    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3TA23, Q3V1Y7
    Related
    ENSMUSP00000129811.2, ENSMUST00000168747.3
    Conserved Domains (1) summary
    cd02073
    Location:65 → 1203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    58305896..58479783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540581.4 → XP_006540644.1  phospholipid-transporting ATPase VA isoform X1

    See identical proteins and their annotated locations for XP_006540644.1

    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3TA23, Q3V1Y7
    Conserved Domains (1) summary
    cd02073
    Location:65 → 1203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  2. XM_006540580.4 → XP_006540643.1  phospholipid-transporting ATPase VA isoform X1

    See identical proteins and their annotated locations for XP_006540643.1

    UniProtKB/Swiss-Prot
    O54827, Q8R3B8
    UniProtKB/TrEMBL
    Q3TA23, Q3V1Y7
    Conserved Domains (1) summary
    cd02073
    Location:65 → 1203
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  3. XM_036152612.1 → XP_036008505.1  phospholipid-transporting ATPase VA isoform X2

    Conserved Domains (1) summary
    cl21460
    Location:2 → 876
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. XM_006540583.5 → XP_006540646.1  phospholipid-transporting ATPase VA isoform X4

    Conserved Domains (1) summary
    cd02073
    Location:258 → 763
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

  5. XM_017321952.3 → XP_017177441.1  phospholipid-transporting ATPase VA isoform X3

    Conserved Domains (1) summary
    cd02073
    Location:1 → 835
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. XR_882009.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54827.4 GenPept UniProtKB/Swiss-Prot:O54827

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