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Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 [ Mus musculus (house mouse) ]

Gene ID: 11988, updated on 2-Nov-2024

Summary

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Official Symbol
Slc7a2provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2provided by MGI
Primary source
MGI:MGI:99828
See related
Ensembl:ENSMUSG00000031596 AllianceGenome:MGI:99828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tea; 20.5; Cat2; Atrc2; CAT-2
Summary
Enables L-arginine transmembrane transporter activity. Involved in L-arginine transmembrane transport and regulation of macrophage activation. Acts upstream of or within several processes, including macrophage activation; nitric oxide biosynthetic process; and nitric oxide production involved in inflammatory response. Located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human SLC7A2 (solute carrier family 7 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 24.2), liver E18 (RPKM 9.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Slc7a2 in Genome Data Viewer
Location:
8 A4; 8 23.89 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (41315404..41375107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (40862341..40922070)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21277 Neighboring gene platelet-derived growth factor receptor-like Neighboring gene STARR-positive B cell enhancer ABC_E9310 Neighboring gene STARR-seq mESC enhancer starr_21279 Neighboring gene RIKEN cDNA B430010I23 gene Neighboring gene mitochondrial tumor suppressor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulating gene expression through RNA nuclear retention. Prasanth KV, et al. Cell, 2005 Oct 21. PMID 16239143
  2. L-arginine and cationic amino acid transporter 2B regulate growth and survival of Leishmania amazonensis amastigotes in macrophages. Wanasen N, et al. Infect Immun, 2007 Jun. PMID 17387163, Free PMC Article
  3. Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. Thompson RW, et al. PLoS Pathog, 2008 Mar 14. PMID 18369473, Free PMC Article
  4. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Niese KA, et al. Respir Res, 2010 Jun 24. PMID 20576117, Free PMC Article
  5. Cloning of the rat ecotropic retroviral receptor and studies of its expression in intestinal tissues. Puppi M, et al. Proc Soc Exp Biol Med, 1995 May. PMID 7724615

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
    Title: Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease.
  2. Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
    Title: Integrated Amino Acids and Transcriptome Analysis Reveals Arginine Transporter SLC7A2 Is a Novel Regulator of Myogenic Differentiation.
  3. SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
    Title: SLC3A2 and SLC7A2 Mediate the Exogenous Putrescine-Induced Adipocyte Differentiation.
  4. Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
    Title: Molecular Determinants for Nitric Oxide Regulation of the Murine Cationic Amino Acid Transporter CAT-2A.
  5. Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
    Title: Characterisation of genes differentially expressed in macrophages by virulent and attenuated Mycobacterium tuberculosis through RNA-Seq analysis.
  6. In wild-type mice exposed to hyperoxia, the exhaled nitric oxide (exNO) was twofold greater than in wild-type mice exposed to normoxia ( P < 0.005), whereas in slc7a2(-/-) mice there was no significant difference between exNO in animals exposed to hyperoxia or normoxia ( P = 0.95). These results are consistent with our hypothesis that lack of CAT-2 protects mice from acute lung injury.
    Title: Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury.
  7. data reveal that SLC7A2 has a significant role in the protection from colitis-associated carcinogenesis (CAC) in the setting of chronic colitis, and suggest that the decreased SLC7A2 in inflammatory bowel disease (IBD) may contribute to CAC risk.
    Title: Loss of solute carrier family 7 member 2 exacerbates inflammation-associated colon tumorigenesis.
  8. A time-dependent decrease in serum and tissue ADMA and increase in mRNA expression of DDAH-1 and PRMT-1 as well as higher rates of mRNA expression of CAT-1 and lower rates of CAT-2A and CAT-2B were found after 8-week MCD diet.
    Title: MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters.
  9. In the absence of CAT2, Myeloid-derived suppressor cells display diminished capacity for controlling T cell immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antitumor activity.
    Title: Expression of Cationic Amino Acid Transporter 2 Is Required for Myeloid-Derived Suppressor Cell-Mediated Control of T Cell Immunity.
  10. demonstration of how most nuclear-retained CTN-RNAs stabilize at the periphery of paraspeckles, how CTN-RNA regulates its protein-coding partner, and how the mCAT2 gene can maintain a stable expression
    Title: Dynamical analysis of mCAT2 gene models with CTN-RNA nuclear retention.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-arginine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ornithine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-arginine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within L-arginine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nitric oxide production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of macrophage activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cationic amino acid transporter 2
Names
T-cell early activation protein
amino acid transporter, cationic 2 (low affinity)
cationic amino acid transporter 2A
cationic amino acid transporter 2B
low affinity cationic amino acid transporter 2
solute carrier family 7 member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044740.2 → NP_001038205.1  cationic amino acid transporter 2 isoform 2

    See identical proteins and their annotated locations for NP_001038205.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is longer but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC116511
    Consensus CDS
    CCDS40327.1
    UniProtKB/TrEMBL
    E9QJY0
    Related
    ENSMUSP00000096414.4, ENSMUST00000098816.10
    Conserved Domains (1) summary
    TIGR00906
    Location:5 → 608
    2A0303; cationic amino acid transport permease

  2. NM_007514.3 → NP_031540.2  cationic amino acid transporter 2 isoform 1

    See identical proteins and their annotated locations for NP_031540.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC116511, AI158848, BB648063, L11600
    Consensus CDS
    CCDS22258.1
    UniProtKB/Swiss-Prot
    E9QPL9, P18581, Q38RA6, Q3TB99, Q3U3R5
    UniProtKB/TrEMBL
    E9QJY0
    Related
    ENSMUSP00000058866.9, ENSMUST00000057784.15
    Conserved Domains (1) summary
    TIGR00906
    Location:5 → 607
    2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    41315404..41375107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509253.5 → XP_006509316.1  cationic amino acid transporter 2 isoform X4

    See identical proteins and their annotated locations for XP_006509316.1

    UniProtKB/TrEMBL
    E9QJY0
    Conserved Domains (1) summary
    TIGR00906
    Location:5 → 608
    2A0303; cationic amino acid transport permease

  2. XM_006509252.4 → XP_006509315.1  cationic amino acid transporter 2 isoform X3

    UniProtKB/TrEMBL
    E9QJY0
    Conserved Domains (1) summary
    TIGR00906
    Location:26 → 629
    2A0303; cationic amino acid transport permease

  3. XM_006509250.5 → XP_006509313.1  cationic amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    E9QJY0
    Conserved Domains (1) summary
    TIGR00906
    Location:67 → 670
    2A0303; cationic amino acid transport permease

  4. XM_006509251.5 → XP_006509314.2  cationic amino acid transporter 2 isoform X2

    UniProtKB/Swiss-Prot
    E9QPL9, P18581, Q38RA6, Q3TB99, Q3U3R5
    UniProtKB/TrEMBL
    E9QJY0
    Related
    ENSMUSP00000112848.2, ENSMUST00000118432.2
    Conserved Domains (1) summary
    TIGR00906
    Location:5 → 607
    2A0303; cationic amino acid transport permease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18581.3 GenPept UniProtKB/Swiss-Prot:P18581

Gene LinkOut

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