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Vps51 VPS51 subunit of GARP complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 120097389, updated on 2-Nov-2024

Summary

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Official Symbol
Vps51provided by RGD
Official Full Name
VPS51 subunit of GARP complexprovided by RGD
Primary source
RGD:2319165
See related
EnsemblRapid:ENSRNOG00000020996 AllianceGenome:RGD:2319165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560544
Summary
Predicted to be involved in several processes, including brain morphogenesis; endocytic recycling; and vesicle-mediated cholesterol transport. Predicted to act upstream of or within lysosomal transport and retrograde transport, endosome to Golgi. Located in recycling endosome and trans-Golgi network. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 13. Orthologous to human VPS51 (VPS51 subunit of GARP complex). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See Vps51 in Genome Data Viewer
Location:
1q43
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212789721..212799708, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203360434..203370422, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger, HIT-type containing 2 Neighboring gene transmembrane 7 superfamily member 2 Neighboring gene microRNA 6315 Neighboring gene transmembrane protein 262 Neighboring gene zinc finger protein-like 1 Neighboring gene cell division cycle associated 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. Pérez-Victoria FJ, et al. Mol Biol Cell, 2010 Oct 1. PMID 20685960, Free PMC Article
  2. TSSC1 is novel component of the endosomal retrieval machinery. Gershlick DC, et al. Mol Biol Cell, 2016 Sep 15. PMID 27440922, Free PMC Article
  3. EARP is a multisubunit tethering complex involved in endocytic recycling. Schindler C, et al. Nat Cell Biol, 2015 May. PMID 25799061, Free PMC Article
  4. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, et al. PLoS Genet, 2016 May. PMID 27191843, Free PMC Article
  5. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in brain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytic recycling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of EARP complex ISO
Inferred from Sequence Orthology
more info
  
part_of GARP complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 51 homolog
Names
VPS51 GARP complex subunit
chromosome 11 open reading frame 2-like
vacuolar protein sorting 51 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001416313.1 → NP_001403242.1  vacuolar protein sorting-associated protein 51 homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6HZC7, F1M4I4
    Related
    ENSRNOP00000028495.7, ENSRNOT00000028495.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212789721..212799708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106328.1: Suppressed sequence

    Description
    NM_001106328.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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