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Baat bile acid-Coenzyme A: amino acid N-acyltransferase [ Mus musculus (house mouse) ]

Gene ID: 12012, updated on 2-Nov-2024

Summary

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Official Symbol
Baatprovided by MGI
Official Full Name
bile acid-Coenzyme A: amino acid N-acyltransferaseprovided by MGI
Primary source
MGI:MGI:106642
See related
Ensembl:ENSMUSG00000039653 AllianceGenome:MGI:106642
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAT
Summary
Enables N-acyltransferase activity. Acts upstream of or within bile acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in disease of metabolism. Orthologous to human BAAT (bile acid-CoA:amino acid N-acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 17.8), liver E18 (RPKM 3.3) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Baat in Genome Data Viewer
Location:
4 B1; 4 26.51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49489416..49507915, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49489416..49507915, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acyl-coenzyme A amino acid N-acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_10184 Neighboring gene predicted gene, 26424 Neighboring gene predicted gene, 33009 Neighboring gene predicted gene, 32894 Neighboring gene predicted gene, 52736 Neighboring gene mitochondrial ribosomal protein L50

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Baat Gene Knockout Alters Post-Natal Development, the Gut Microbiome, and Reveals Unusual Bile Acids in Mice. Neugebauer KA, et al. J Lipid Res, 2022 Dec. PMID 36243101, Free PMC Article
  2. Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice. Alrehaili BD, et al. Hepatol Commun, 2022 Oct. PMID 35866568, Free PMC Article
  3. Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26. Contos JJ, et al. Genomics, 1998 Aug 1. PMID 9721207
  4. Cloning, expression, and chromosomal localization of mouse liver bile acid CoA:amino acid N-acyltransferase. Falany CN, et al. J Lipid Res, 1997 Jun. PMID 9215542
  5. Genetic mapping of the C-type natriuretic peptide receptor (Npr2) gene to mouse chromosome 4. Nuglozeh E, et al. Mamm Genome, 1997 Aug. PMID 9250880

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables choloyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine N-choloyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine N-choloyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables medium-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables very long-chain fatty acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables very long-chain fatty acyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in acyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid conjugation IEA
Inferred from Electronic Annotation
more info
  
involved_in bile acid conjugation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bile acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in taurine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
bile acid-CoA:amino acid N-acyltransferase
Names
BACAT
bile acid-CoA thioesterase
bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase
choloyl-CoA hydrolase
glycine N-choloyltransferase
long-chain fatty-acyl-CoA hydrolase
taurine N-acyltransferase
NP_031545.2
XP_006537628.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007519.3 → NP_031545.2  bile acid-CoA:amino acid N-acyltransferase

    See identical proteins and their annotated locations for NP_031545.2

    Status: VALIDATED

    Source sequence(s)
    AA255212, AK017923, BB800891, BY080271, CB947692, U95215
    Consensus CDS
    CCDS18173.1
    UniProtKB/Swiss-Prot
    A2AKK7, O08833, Q8C1I3, Q91X34
    Related
    ENSMUSP00000041983.3, ENSMUST00000043056.9
    Conserved Domains (2) summary
    pfam08840
    Location:207 → 414
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    pfam04775
    Location:14 → 140
    Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49489416..49507915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537565.4 → XP_006537628.1  bile acid-CoA:amino acid N-acyltransferase isoform X1

    Conserved Domains (1) summary
    pfam08840
    Location:34 → 241
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91X34.1 GenPept UniProtKB/Swiss-Prot:Q91X34

Gene LinkOut

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