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NXPE2 neurexophilin and PC-esterase domain family member 2 [ Homo sapiens (human) ]

Gene ID: 120406, updated on 5-Mar-2024

Summary

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Official Symbol
NXPE2provided by HGNC
Official Full Name
neurexophilin and PC-esterase domain family member 2provided by HGNC
Primary source
HGNC:HGNC:26331
See related
Ensembl:ENSG00000204361 AllianceGenome:HGNC:26331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM55B
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon (RPKM 2.7), salivary gland (RPKM 0.7) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
11q23.2-q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (114464276..114813702)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (114474694..114824997)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114549249..114577791)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene nocturnin pseudogene Neighboring gene MPRA-validated peak1476 silencer Neighboring gene small nucleolar RNA U13 Neighboring gene RNA exonuclease 2 Neighboring gene histone deacetylase 2 pseudogene Neighboring gene neurexophilin and PC-esterase domain family member 2 pseudogene 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:114473708-114474907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3916 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3917 Neighboring gene neurexophilin and PC-esterase domain family member 1 Neighboring gene neurexophilin and PC-esterase domain family member 4 Neighboring gene uncharacterized LOC105369506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114717517-114718016 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:114757957-114759156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:114800269-114800769 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115035341-115035883 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:115079540-115080739 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:115093260-115094068 Neighboring gene NANOG hESC enhancer GRCh37_chr11:115141547-115142048 Neighboring gene cell adhesion molecule 1 Neighboring gene Sharpr-MPRA regulatory region 15022 Neighboring gene uncharacterized LOC105369509 Neighboring gene CADM1 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Ivarsson Y, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550280, Free PMC Article
  2. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25224

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NXPE family member 2
Names
family with sequence similarity 55, member B
protein FAM55B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182495.6 → NP_872301.2  NXPE family member 2

    See identical proteins and their annotated locations for NP_872301.2

    Status: VALIDATED

    Source sequence(s)
    AP002774
    Consensus CDS
    CCDS44738.1
    UniProtKB/Swiss-Prot
    Q2NKI8, Q96DL1
    Related
    ENSP00000374237.4, ENST00000389586.6
    Conserved Domains (1) summary
    pfam06312
    Location:142 → 274
    Neurexophilin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    114464276..114813702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017209.2 → XP_016872698.1  NXPE family member 2 isoform X2

    Conserved Domains (1) summary
    pfam06312
    Location:118 → 250
    Neurexophilin; Neurexophilin

  2. XM_017017207.2 → XP_016872696.1  NXPE family member 2 isoform X2

    Conserved Domains (1) summary
    pfam06312
    Location:118 → 250
    Neurexophilin; Neurexophilin

  3. XM_011542604.3 → XP_011540906.1  NXPE family member 2 isoform X2

    See identical proteins and their annotated locations for XP_011540906.1

    Conserved Domains (1) summary
    pfam06312
    Location:118 → 250
    Neurexophilin; Neurexophilin

  4. XM_017017212.2 → XP_016872701.1  NXPE family member 2 isoform X4

  5. XM_017017211.2 → XP_016872700.1  NXPE family member 2 isoform X3

  6. XM_017017206.2 → XP_016872695.1  NXPE family member 2 isoform X1

RNA

  1. XR_001747769.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    114474694..114824997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367681.1 → XP_054223656.1  NXPE family member 2 isoform X2

  2. XM_054367680.1 → XP_054223655.1  NXPE family member 2 isoform X2

  3. XM_054367679.1 → XP_054223654.1  NXPE family member 2 isoform X2

  4. XM_054367682.1 → XP_054223657.1  NXPE family member 2 isoform X2

  5. XM_054367684.1 → XP_054223659.1  NXPE family member 2 isoform X4

  6. XM_054367683.1 → XP_054223658.1  NXPE family member 2 isoform X3

  7. XM_054367678.1 → XP_054223653.1  NXPE family member 2 isoform X1

RNA

  1. XR_008488342.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DL1.2 GenPept UniProtKB/Swiss-Prot:Q96DL1

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