Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl2a1bprovided by MGI
Official Full Name: B cell leukemia/lymphoma 2 related protein A1bprovided by MGI
Primary source: MGI:MGI:1278326
See related: Ensembl:ENSMUSG00000089929 AllianceGenome:MGI:1278326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A1-b
Summary: Predicted to enable BH domain binding activity and channel activity. Predicted to be involved in apoptotic signaling pathway; mitochondrial fusion; and positive regulation of apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Is expressed in craniocervical region bone; hemolymphoid system; musculature; and respiratory system. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in spleen adult (RPKM 7.7), thymus adult (RPKM 5.5) and 20 other tissues See more
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Genomic context

Location:: 9 E3.1; 9 47.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (89081326..89089891)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (89199273..89207838)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493091

U23778 (e-PCR)
- UniSTS:159905

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH domain binding	ISO Inferred from Sequence Orthology more info
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B-cell leukemia/lymphoma 2 related protein A1b

Names: anti-apoptotic protein A1-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.