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Bicd1 BICD cargo adaptor 1 [ Mus musculus (house mouse) ]

Gene ID: 12121, updated on 2-Nov-2024

Summary

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Official Symbol
Bicd1provided by MGI
Official Full Name
BICD cargo adaptor 1provided by MGI
Primary source
MGI:MGI:1101760
See related
Ensembl:ENSMUSG00000003452 AllianceGenome:MGI:1101760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
bic-D 1; B830009D06Rik
Summary
Enables proteinase activated receptor binding activity. Involved in microtubule anchoring at microtubule organizing center; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; and stress granule assembly. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in Golgi apparatus and cytosol. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in cerebellum adult (RPKM 3.4), CNS E18 (RPKM 3.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Bicd1 in Genome Data Viewer
Location:
6 G3; 6 78.94 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (149310322..149464827)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (149408824..149563329)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene Neighboring gene MRT4, mRNA turnover 4, homolog pseudogene Neighboring gene predicted gene 15785 Neighboring gene STARR-seq mESC enhancer starr_17873 Neighboring gene STARR-seq mESC enhancer starr_17874 Neighboring gene STARR-seq mESC enhancer starr_17875 Neighboring gene predicted gene, 38931 Neighboring gene predicted gene, 21814

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry. Terawaki S, et al. Biochem Biophys Res Commun, 2015 May 1. PMID 25796327
  2. Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. Terenzio M, et al. EMBO J, 2014 Jul 17. PMID 24920579, Free PMC Article
  3. A human homologue (BICD1) of the Drosophila bicaudal-D gene. Baens M, et al. Genomics, 1997 Nov 1. PMID 9367685
  4. Isolation and regional assignment of human chromosome 12p cDNAs. Baens M, et al. Genomics, 1995 Sep 1. PMID 8530100
  5. A novel protease-activated receptor-1 interactor, Bicaudal D1, regulates G protein signaling and internalization. Swift S, et al. J Biol Chem, 2010 Apr 9. PMID 20164183, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
    Title: PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.
  2. findings suggest a molecular basis for cargo recognition and autoinhibition of BICD proteins during dynein-dependent intracellular retrograde transport
    Title: Structural basis for cargo binding and autoinhibition of Bicaudal-D1 by a parallel coiled-coil with homotypic registry.
  3. BICD1 regulates neurotrophin signalling by modulating the endosomal sorting of internalised ligand-activated receptors.
    Title: Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.
  4. Impairment of retrograde transport by knockdown of DHC1 or BicD1 inhibits stress-granule formation and P-body growth upon stress.
    Title: Dynein and kinesin regulate stress-granule and P-body dynamics.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4125

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal anchor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytoskeletal anchor activity IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal anchor activity ISO
Inferred from Sequence Orthology
more info
  
enables dynactin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynactin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein complex binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables proteinase activated receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables proteinase activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule anchoring at microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule anchoring at microtubule organizing center IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in minus-end-directed organelle transport along microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in viral process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in secretory vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein bicaudal D homolog 1
Names
bicaudal D homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112796.2 → NP_001106267.1  protein bicaudal D homolog 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 3' coding region and differs in the 3' UTR, compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC164090, AK043650, AK051379, AK082523
    Consensus CDS
    CCDS51962.1
    UniProtKB/TrEMBL
    Q5DTM3
    Related
    ENSMUSP00000107138.3, ENSMUST00000111513.9
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  2. NM_009753.4 → NP_033883.2  protein bicaudal D homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_033883.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AC164090, AK043650, AK051379, AK082523
    Consensus CDS
    CCDS39723.1
    UniProtKB/Swiss-Prot
    O55206, Q8BQ18, Q8BR07, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7
    UniProtKB/TrEMBL
    Q5DTM3
    Related
    ENSMUSP00000084039.5, ENSMUST00000086829.11
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    149310322..149464827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507014.4 → XP_006507077.1  protein bicaudal D homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_006507077.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  2. XM_006507017.4 → XP_006507080.1  protein bicaudal D homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_006507080.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  3. XM_006507015.4 → XP_006507078.1  protein bicaudal D homolog 1 isoform X2

    See identical proteins and their annotated locations for XP_006507078.1

    UniProtKB/TrEMBL
    B2KG46, Q5DTM3
    Related
    ENSMUSP00000003544.8, ENSMUST00000003544.14
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  4. XM_006507016.4 → XP_006507079.1  protein bicaudal D homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_006507079.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  5. XM_006507018.4 → XP_006507081.1  protein bicaudal D homolog 1 isoform X6

    See identical proteins and their annotated locations for XP_006507081.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  6. XM_036165765.1 → XP_036021658.1  protein bicaudal D homolog 1 isoform X8

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  7. XM_030255123.1 → XP_030110983.1  protein bicaudal D homolog 1 isoform X7

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  8. XM_006507023.4 → XP_006507086.1  protein bicaudal D homolog 1 isoform X11

    See identical proteins and their annotated locations for XP_006507086.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  9. XM_006507020.4 → XP_006507083.1  protein bicaudal D homolog 1 isoform X10

    See identical proteins and their annotated locations for XP_006507083.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  10. XM_006507019.5 → XP_006507082.1  protein bicaudal D homolog 1 isoform X9

    See identical proteins and their annotated locations for XP_006507082.1

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  11. XM_036165764.1 → XP_036021657.1  protein bicaudal D homolog 1 isoform X4

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  12. XM_036165766.1 → XP_036021659.1  protein bicaudal D homolog 1 isoform X12

    UniProtKB/TrEMBL
    Q5DTM3
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

  13. XM_006507024.4 → XP_006507087.1  protein bicaudal D homolog 1 isoform X13

    See identical proteins and their annotated locations for XP_006507087.1

    UniProtKB/TrEMBL
    G3UXK5, Q5DTM3
    Related
    ENSMUSP00000133727.2, ENSMUST00000173408.8
    Conserved Domains (1) summary
    pfam09730
    Location:74 → 799
    BicD; Microtubule-associated protein Bicaudal-D

RNA

  1. XR_003956156.1 RNA Sequence

  2. XR_004942913.1 RNA Sequence

  3. XR_869604.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BR07.2 GenPept UniProtKB/Swiss-Prot:Q8BR07

Gene LinkOut

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