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LOC121530603 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89959457-89959966 [ Homo sapiens (human) ]

Gene ID: 121530603, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121530603
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89959457-89959966
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. A subregion was also validated as an enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 12:CtcfO, distal CTCF/candidate insulator with open chromatin). [provided by RefSeq, Jan 2023]
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Genomic context

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Location:
15q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89416226..89416735)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87172256..87172765)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (89959589..89959883)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89910855-89911468 Neighboring gene MIR9-3 host gene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89913278-89914160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89914161-89915042 Neighboring gene uncharacterized LOC107984777 Neighboring gene microRNA 9-3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89943355-89943880 Neighboring gene uncharacterized LOC105371031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89943881-89944405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10052 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:89950909-89951506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89959967-89960475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89977117-89977646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89984167-89984846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89984847-89985526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:89988016-89988870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:89991872-89992466 Neighboring gene uncharacterized LOC105370964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6798 Neighboring gene uncharacterized LOC112268153 Neighboring gene Rh family C glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90029819-90030319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90035105-90035610

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • Sharpr-MPRA regulatory region 3595

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074801.2 

    Range
    101..610
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    89416226..89416735
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    87172256..87172765
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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