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LOC121627807 Sharpr-MPRA regulatory region 691 [ Homo sapiens (human) ]

Gene ID: 121627807, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121627807
Gene description
Sharpr-MPRA regulatory region 691
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating non-DNase unmatched - State 21:Repr, strong Polycomb repression). [provided by RefSeq, Jun 2021]
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Genomic context

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Location:
17q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74404250..74404544)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75294794..75295088)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72400389..72400683)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72364259-72365247 Neighboring gene G protein-coupled receptor 142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8931 Neighboring gene uncharacterized LOC124904055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72382905-72383799 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390282-72390782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72390783-72391283 Neighboring gene RNA, 5S ribosomal pseudogene 448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72420638-72421138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72422872-72423636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8932 Neighboring gene G protein-coupled receptor class C group 5 member C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440360-72440904 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:72440905-72441448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_074997.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74404250..74404544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75294794..75295088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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